Evidence map›Paper›PMID 39523450›Full record

ReviewGut microbes

Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases.

Muhammad Usman Munir, Syed Aoun Ali, Ka Hang Karen Chung, Aleksandr Kakinen, Ibrahim Javed, Thomas Paul Davis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Marine drugs · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muhammad Usman MunirAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld, Australia.
Syed Aoun AliAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld, Australia.
Ka Hang Karen ChungAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld, Australia.
Aleksandr KakinenAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld, Australia.
Ibrahim JavedAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld, Australia.
Thomas Paul DavisAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld, Australia.ORCID 0000-0003-2581-4986

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deciphering the molecular communications along the gut-brain axis can help in understanding the pathophysiology of neurodegenerative diseases and exploiting the gut microbiome for therapeutics. However, gut microbes and their metabolites have a multifaceted role in mediating both brain physiology and neurodegenerative pathology. There is a lack of understanding of how and when this role is tipped in neurodegenerative diseases and what are those contributing factors, both at local (gut) and distal (neuronal) levels, that drive this imbalance. Here we have reviewed the gut microbiome and its metabolites in the context of the gut-brain axis and summarized how different factors such as gut-microbial diversity, their metabolites, the role of the native immune system and the integrity of gut epithelial and blood-brain barriers are interconnected and collectively define the involvement of gut-microbiome in neurodegenerative pathologies. It also underlines the need for multidisciplinary tools and animal models to simultaneously reflect on many of these factors and to better correlate with clinical observations and data obtained from human biopsies and fecal samples. Harnessing the gut-brain axis will herald a paradigm shift in medicine for neurodegenerative diseases and aging, emphasizing the significance of the microbiome in the broader spectrum of health and disease.

Indexed as

Brain-Gut AxisGastrointestinal MicrobiomeNeurodegenerative DiseasesAnimalsBrainHumansMetabolomicsSymbiosisagingAlzheimer’sGut-brain axismicrobial metabolitesmicrobiomeneurodegenerationParkinson’s

Identifiers

PMID39523450
PMCPMC11556280

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.