Evidence map›Paper›PMID 39523406›Full record

ArticleDiabetology & metabolic syndrome2024

Lifestyle intervention improves cardiometabolic profiles among children with metabolically healthy and metabolically unhealthy obesity.

Ruziana Mona Wan Mohd Zin, Muhammad Yazid Jalaludin, Fuziah Md Zain, Janet Yeow Hua Hong, Nur Zati Iwani Ahmad Kamil, Abdul Halim Mokhtar, Wan Nazaimoon Wan Mohamud

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02212873 (School-based Intervention Program - My Body is Fit and Fabulous), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02212873 nacompletednot on this map

School-based Intervention Program - My Body is Fit and Fabulous

TypeinterventionalSponsorMinistry of Health, MalaysiaRan2014 to 2014Enrolled332ConditionsOverweight, ObeseArmsMyBFF@school program
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruziana Mona Wan Mohd ZinEndocrine and Metabolic Unit, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia. ruzianamona@moh.gov.my.
Muhammad Yazid JalaludinDepartment of Paediatrics, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. yazidjal@um.edu.my.
Fuziah Md ZainDepartment of Paediatrics, Hospital Putrajaya, Ministry of Health Malaysia, Putrajaya, Malaysia.
Janet Yeow Hua HongDepartment of Paediatrics, Hospital Putrajaya, Ministry of Health Malaysia, Putrajaya, Malaysia.
Nur Zati Iwani Ahmad KamilEndocrine and Metabolic Unit, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia.
Abdul Halim MokhtarUnit of Sports Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Wan Nazaimoon Wan MohamudEndocrine and Metabolic Unit, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam, Selangor, Malaysia.

Funding

Kementerian Kesihatan Malaysia NMRR-13-439-16563
6 · The paper itself

Abstract

backgroundIn recent years, there has been a surge of interest in the metabolic phenotype among children with obesity characterized by the absence of associated cardiometabolic risk factors (CRFs), known as metabolically healthy obesity (MHO), as opposed to those with metabolically unhealthy obesity (MUO). This study investigated the effect of lifestyle intervention on CRFs among children with MHO and MUO.

methodsA total of 102 school-aged children with obesity (54 girls and 48 boys) aged 8-16 years completed a 16-week school-based lifestyle modification intervention program, MyBFF@school Phase I. The intervention consisted of physical activity, healthy eating promotion, and psychological empowerment. MHO and MUO statuses were defined based on the 2018 consensus-based criteria. Fasting venous blood collection, body composition measurement, clinical assessment and physical fitness testing were conducted at baseline and at the end of week 16.

resultsAfter the intervention, the CRFs of the children with MUO improved with significant decreases in systolic (p < 0.001) and diastolic (p = 0.01) blood pressure and a significant increase in high-density lipoprotein cholesterol (HDL-C) (p = 0.005), while the CRFs of the children with MHO had a significant decrease in uric acid (p = 0.04). Additionally, 51.6% of the children with MHO transitioned to the MUO, while 26.8% of the children with MUO crossed over to the MHO at the end of the intervention. Furthermore, the odds of having high systolic blood pressure among children with MUO were 59% lower at week-16 than at baseline (OR = 0.41 (95% CI = 0.18, 0.92), p = 0.03).

conclusionsOur findings demonstrated that CRFs improved more prominently among children with MUO following the intervention. More importantly, our findings indicate that MHO in children is transient, hence, strategies to protect children against MUO are warranted.

trial registrationClinicalTrials.gov NCT02212873.

Indexed as

Cardiometabolic risk factorsLifestyle interventionMetabolic phenotypePaediatric obesitySchool-based interventionSchool children

Identifiers

PMID39523406
PMCPMC11552173

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.