ArticleOncogene2025
Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production.
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Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
–field-weighted citation impact
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Safety and Efficacy of Eflornithine in Patients with Gastric Precancerous Lesions: A Double-Blinded, Randomized Clinical Trial.Cancer prevention research (Philadelphia, Pa.) · 2026Trial
- Article
- The Oral-Gastric Microbial Axis in Gastric Cancer: Mechanisms Underlying Development and Progression.Cancers · 2026Review
- Mitochondrial Stress inAntioxidants (Basel, Switzerland) · 2026Review
- Epithelial hypusination regulates Helicobacter pylori-induced gastric inflammation.Amino acids · 2026Article
- Feeding the invaders: how metabolic imbalance shapes infection and biofilm development.FEMS microbiology reviews · 2026Review
- Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Digestive System Tumors: Modulating the Chronic Inflammatory Microenvironment.International journal of nanomedicine · 2026Review
- Review
- Epithelial Hypusination Regulates Helicobacter pylori-induced Gastric Inflammation.Research square · 2025Article
- Transcriptomics combined withTranslational cancer research · 2025Article
- Helicobacter pylori and gastric cancer: mechanisms and new perspectives.Journal of hematology & oncology · 2025Review
- Alterations in polyamine metabolism induced by the pathogen Helicobacter pylori: Implications for gastric inflammation and carcinogenesis.Methods in enzymology · 2025Article
- Article
Corrections and comments
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Authors and funding
19 authors.
Kara M McNamaraDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Johanna C SierraDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Yvonne L LatourDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Caroline V HawkinsDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Mohammad AsimDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Kamery J WilliamsDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Daniel P BarryDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.ORCID 0000-0002-3972-3914
Margaret M AllamanDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.ORCID 0000-0002-2803-1365
Irene Zagol-IkapitteWarren Center for Neuroscience Drug Discovery, Vanderbilt University, Franklin, TN, 37067, USA.
Paula B LuisDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
Claus SchneiderDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
Alberto G DelgadoDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
M Blanca PiazueloDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Regina N TyreeDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Kate S CarsonDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Yash A ChoksiDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.ORCID 0000-0003-1717-4472
Lori A CoburnDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.ORCID 0000-0003-3249-9806
Alain P GobertDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.ORCID 0000-0001-7535-539X
Keith T WilsonDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. keith.wilson@vumc.org.ORCID 0000-0003-4421-1830
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MRole of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2009 to 2026
$27.5MProject 3 - Molecular Signatures of Gastric Carcinogenesis in the Host Response to H. pyloriP01CA028842 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 1985 to 2019
$15.8MMULTIDISCIPLINARY BASIC RESEARCH TRAINING IN CANCERT32CA009592 · NCI · VANDERBILT UNIVERSITY · PI Justin M Balko, Julie A Rhoades (Sterling) · 1987 to 2026
$10.4MSpermidine as a New Therapy for Colitis and Chemopreventive for Colitis-associated CarcinogenesisR01DK128200 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 2021 to 2024
$2.7MImmunological Mechanisms of Disease Training ProgramT32AI138932 · NIAID · VANDERBILT UNIVERSITY · PI MAJOR, AMY S, RATHMELL, JEFFREY C. · 2019 to 2023
$1.4MThe Macrophage Reverse Transsulfuration Pathway: A Novel Mediator of Helicobacter pylori ImmunopathogenesisR21AI142042 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 2019 to 2020
$468kEfficacy of an Electrophile Scavenger in the Prevention of Gastrointestinal Inflammatory CarcinogenesisR41CA257262 · NCI · MTI BIOTECH, INC. · PI RATHMACHER, JOHN A, WILSON, KEITH T. · 2021 to 2021
$400kPolyamine Dysregulation in the Gastric Epithelium during Helicobacter pylori Infection and its Impact on Gastric CarcinogenesisF31CA278330 · NCI · VANDERBILT UNIVERSITY · PI MCNAMARA, KARA · 2023 to 2025
$72kArginine Availability and Metabolism in the Immune Evasion of H. pyloriI01BX001453 · VA · VETERANS HEALTH ADMINISTRATION · PI WILSON, KEITH T. · 2012 to 2019
–CCL11 as a New Therapeutic Target for Colitis and Colon CancerI01BX004366 · VA · VETERANS HEALTH ADMINISTRATION · PI COBURN, LORI A · 2019 to 2022
–Dysregulated Polyamine Metabolism in H. pylori-associated Gastric Inflammation and Disease ProgressionI01CX002171 · VA · VETERANS HEALTH ADMINISTRATION · PI Keith T. Wilson · 2020 to 2026
–BLRD VA I01 BX001453BLRD VA I01 BX004366BLRD VA IK2 BX004648CSRD VA I01 CX002171CSRD VA I01 CX002473CSRD VA I01 CX002662NCI NIH HHS F31 CA278330NCI NIH HHS P01 CA028842NCI NIH HHS P01 CA116087NIAID NIH HHS T32 AI138932NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK128200U.S. Department of Defense (United States Department of Defense) W81XWH-18-1-0301U.S. Department of Defense (United States Department of Defense) W81XWH-21-1-0617U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) F31CA278330U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P01CA028842U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P01CA116087U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R41CA257262U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) T32CA009592U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI142042U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI138932U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK128200U.S. Department of Veterans Affairs (Department of Veterans Affairs) I01BX001453U.S. Department of Veterans Affairs (Department of Veterans Affairs) I01BX004366U.S. Department of Veterans Affairs (Department of Veterans Affairs) I01CX002171U.S. Department of Veterans Affairs (Department of Veterans Affairs) I01CX002473U.S. Department of Veterans Affairs (Department of Veterans Affairs) IK2BX004748
Abstract
Helicobacter pylori is the primary cause of gastric cancer, and there is a need to discover new molecular targets for therapeutic intervention in H. pylori disease progression. We have previously shown that spermine oxidase (SMOX), the enzyme that catabolizes the back-conversion of the polyamine spermine to spermidine, is upregulated during infection and is associated with increased cancer risk in humans. We sought to determine the direct role of SMOX in gastric carcinogenesis during H. pylori infection. In this study, we demonstrate that transgenic FVB/N insulin-gastrin (INS-GAS) mice that develop gastric carcinoma with H. pylori infection were protected from cancer development with Smox deletion. RNA sequencing revealed that genes associated with the immune system and cancer were downregulated in the infected Smox
Indexed as
AcroleinCarcinogenesisHelicobacter InfectionsHelicobacter pyloriOxidoreductases Acting on CH-NH Group DonorsStomach NeoplasmsAnimalsCell ProliferationDNA DamageHumansMiceMice, KnockoutMice, TransgenicPolyamine OxidaseAcroleinOxidoreductases Acting on CH-NH Group DonorsPolyamine Oxidase
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.