SynthesisJournal of orthopaedic surgery and research2024
Hamstring tendon graft with LARS augmentation showed superior short-term clinical efficacy compared to hamstring tendon alone as graft in ACL reconstruction: a systematic review and meta-analysis.
Synthesis in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The "McFL-LARS" Hybrid Technique: Fascia Lata Autograft and Synthetic Reinforcement for Combined Revision Anterior Cruciate Ligament Reconstruction and Lateral Extra-articular Tenodesis.Arthroscopy techniques · 2026Article
- All-Inside Primary Anterior Cruciate Ligament Reconstruction Using a Combined Polyester Synthetic Graft and Gracilis Tendon Autograft: Modified Technique of a Hybrid 4 × 2 Graft Preparation.Arthroscopy techniques · 2026Article
- Response to the letter to the editor.Journal of orthopaedic surgery and research · 2026Article
- Effectiveness of synthetic vs. autologous ligaments in anterior cruciate ligament reconstruction with remnant preservation: a retrospective cohort study.Frontiers in sports and active living · 2026Article
- A clinical practice review: augmentation of meniscoligamentous structures for primary prevention of knee joint deterioration.Annals of joint · 2026Review
- Article
- LARS-augmented hamstring ACL reconstruction shows better early but similar long-term outcomes compared with hamstring autograft alone: A systematic review and meta-analysis.Journal of experimental orthopaedics · 2026Review
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThere have been emerging clinical trials investigating the efficacy of synthetic-graft-augmented autografts in anterior cruciate ligament reconstruction (ACLR) in recent years. Hamstring tendon and Ligament Augmentation and Reconstruction System (LARS) are both widely discussed graft choices for ACLR. PURPOSE: To compare the clinical efficacy of hamstring tendon grafts with LARS-augmented hamstring tendon grafts in ACLR. STUDY
designSystematic review and meta-analysis.
methodA systematic literature search was performed in PubMed, Embase and the Cochrane Library to identify primary evidence related to the comparison of ACLR with a hamstring tendon (HT) versus a hamstring tendon with LARS (HT + LARS). Quality assessment of the included studies was conducted using Newcastle-Ottawa Scale for non-RCTs. Quantitative analysis was conducted with Reviewer Manager 5.4. The primary outcomes compared were the Lysholm scale, Tegnar activity scale, International Knee Documentation Committee (IKDC) evaluation, KT-1000-based laxity, complication/retear rate and rate of return-to-sports. The secondary outcomes were the Knee Injury and Osteoarthritis Outcomes Score (KOOS), Global Rating of Change (GRC) scale, hop tests, isokinetic knee strength tests and radiographic and arthroscopic evaluations.
resultsSix cohort studies with 710 participants were included in this study. Compared with the HT group, the HT + LARS group had better Lysholm scores at the 1-year follow-up (P = 0.0007) and at the final follow-up (P = 0.04). HT + LARS group had better IKDC scores at the 1-year follow-up (P = 0.003). The HT + LARS group had a better return-to-sports rate in short term. No significant difference in complications or re-surgery was observed. The secondary results revealed superior or non-inferior outcomes in the HT + LARS group.
conclusionsAs grafts for ACLR, the use of hamstring tendons with LARS augmentation, compared with the use of hamstring tendons alone, in the short term, has significantly superior overall functional results and better early sports participation and non-inferior results in other comparisons. In the long term, the use of hamstring tendon with LARS augmentation demonstrated non-inferior results in terms of functional scores, knee stability, knee strength, complications and re-tear rate, etc.
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