ArticleJournal of nanobiotechnology2024
Exploring the cytotoxic and antioxidant properties of lanthanide-doped ZnO nanoparticles: a study with machine learning interpretation.
Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- New Frontiers in AI-Nano Converged Platforms for Intelligent Diagnostics, Therapeutics, and Safety Evaluation.Chem & bio engineering · 2026Review
- Artificial intelligence-guided design of lipid nanoparticles for mRNA delivery.Acta pharmaceutica Sinica. B · 2026Review
- Green Synthesis and Characterization of Silver Nanoparticles UsingInternational journal of microbiology · 2026Article
- From sonochemical synthesis to predictive modeling: Unraveling the antioxidant properties of La-doped CeOUltrasonics sonochemistry · 2026Article
- Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species ofMolecules (Basel, Switzerland) · 2025Article
- Phyto-Mediated Zinc Oxide Nanoparticles fromLife (Basel, Switzerland) · 2025Article
- Machine Learning-Driven Prediction of Reactive Oxygen Species Dynamics for Assessing Nanomaterials' Cytotoxicity.Biomimetics (Basel, Switzerland) · 2025Review
- Lyophilized and Oven-DriedPlants (Basel, Switzerland) · 2025Article
- Targeting Metal Ion Homeostasis for Regulated Cell Death-Amplified Tumor Nanomedicine.International journal of nanomedicine · 2025Review
- Tailoring CdO-CuO-ZnO Mixed Metal Oxide Nanocomposites for Anticancer Activity via Co-Precipitation Method.Nanotechnology, science and applications · 2025Article
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11 authors.
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Abstract
backgroundLanthanide-based nanomaterials offer a promising alternative for cancer therapy because of their selectivity and effectiveness, which can be modified and predicted by leveraging the improved accuracy and enhanced decision-making of machine learning (ML) modeling.
methodsIn this study, erbium (Er
resultsThe (Er, Yb)-doped ZnO NPs exhibited laminar-type morphologies, negative surface charges, and optical bandgaps that vary with the presence of Er
conclusionThis study demonstrates, for the first time, the synthesis of ZnO NPs doped with Er and Yb via a solution polymerization route. According to characterization results, it was unveiled that the effect of optical bandgap variations influenced the cytotoxic performance of the developed lanthanide-doped ZnO NPs, being the undoped ZnO NPs the most cytotoxic ones. The presence alone or in combination of Er and Yb enhanced their scavenging capacity. ML models such as ET and RF efficiently demonstrated that the concentration and cell line type are key parameters that influence the cytotoxicity of (Er, Yb)-doped ZnO NPs achieving high accuracy rates of 98.96% and 98.67%, respectively. This study expands the knowledge of lanthanides as dopants of nanomaterials for biological and medical applications and supports their potential in cancer therapy by integrating robust ML approaches.
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