ArticleInternational dental journal2025
Association of Adult Atopic Dermatitis with Impaired Oral Health and Oral Dysbiosis: A Case-Control Study.
Article in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between asthma, allergic rhinitis, atopic dermatitis, and dental caries: evidence from systematic review with meta-analysis and Mendelian randomisation investigation.Journal of global health · 2026Pooled it
- Characterization of oral microbiome in atopic dermatitis patients treated with dupilumab or upadacitinib.Clinical oral investigations · 2026Article
- From Gut Dysbiosis to Skin Inflammation in Atopic Dermatitis: Probiotics and the Gut-Skin Axis-Clinical Outcomes and Microbiome Implications.International journal of molecular sciences · 2025Review
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Authors and funding
13 authors.
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Abstract
backgroundSystemic alterations in the oral cavity can be reflected in skin disorders like psoriasis. However, data about oral health factors that are affected and controlled mainly by oral microbiota in atopic dermatitis (AD) are sparse. This study compared the oral status and oral microbiota of AD patients and healthy controls.
methodsThis was a prospective sex- and age-matched case-control study comparing adult participants with and without dermatologist-verified AD. A dentist assessed oral health status, and oral flora samples were collected and subjected to 16S rRNA sequencing for microbiome analysis.
resultsForty-five AD participants and 41 non-AD controls were recruited. Compared to the participants in the control group, those with AD had significantly higher plaque levels (P = .04), poorer oral hygiene indices (P = .04), and higher gingival index trends (P = .05). The oral microbiome in the AD group showed significantly higher diversity, both in α and β diversities (P = .001, P = .0007, respectively). Furthermore, AD patients had a significantly increased abundance of taxa correlated with oral diseases and a decreased abundance of bacteria associated with a healthy oral status.
conclusionAD appears to be associated with poor oral health and oral dysbiosis. There is a need to increase both patients' and physicians' awareness of oral health.
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