Evidence map›Paper›PMID 39523096›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2024

[Activation of ALDH2 alleviates hypoxic pulmonary hypertension in mice by upregulating the SIRT1/PGC-1α signaling pathway].

L Wang, F Bian, F Ma, S Fang, Z Ling, M Liu, H Sun, C Fu, S Ni, X Zhao and 5 more

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

L WangDepartment of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
F BianDepartment of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
F MaClinical College of Medicine, Bengbu Medical University, Bengbu 233000, China.
S FangClinical College of Medicine, Bengbu Medical University, Bengbu 233000, China.
Z LingClinical College of Medicine, Bengbu Medical University, Bengbu 233000, China.
M LiuClinical College of Medicine, Bengbu Medical University, Bengbu 233000, China.
H SunDepartment of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
C FuDepartment of Anesthesiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
S NiDepartment of Otolaryngology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
X ZhaoDepartment of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
X FengDepartment of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Z SunDepartment of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
G LuDepartment of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
P KangDepartment of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
S WuDepartment of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether activation of mitochondrial acetal dehydrogenase 2 (ALDH2) alleviates hypoxic pulmonary hypertension by regulating the SIRT1/PGC-1α signaling pathway.

methodsThirty 8-week-old C57 BL/6 mice were randomized into control, hypoxia, and hypoxia +Alda-1 (an ALDH2 activator) group (

resultsThe wild-type mice with hypoxic exposure showed significantly increased RVSP, right ventricular free wall thickness and myocardial expressions of P16

conclusionALDH2 alleviates hypoxiainduced senescence of pulmonary artery smooth muscle cells by upregulating the SIRT1/PGC-1α signaling pathway to alleviate pulmonary hypertension in mice.

Indexed as

Aldehyde Dehydrogenase, MitochondrialHypertension, PulmonaryHypoxiaMice, Inbred C57BLPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSignal TransductionSirtuin 1AnimalsBenzamidesBenzodioxolesMaleMiceMice, KnockoutMyocytes, Smooth MusclePulmonary ArteryUp-RegulationAldehyde Dehydrogenase, MitochondrialALDH2 protein, mouseBenzamidesBenzodioxolesN-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamidePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseSirt1 protein, mouseSirtuin 1ALDH2PGC-1αpulmonary hypertensionSIRT1smooth muscle cell senescence

Identifiers

PMID39523096
PMCPMC11526457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.