Evidence map›Paper›PMID 39522997›Full record

ArticleInternal medicine (Tokyo, Japan)2025

A Rare Case of Primary Hepatic Undifferentiated Pleomorphic Sarcoma: Exploring Cancer-related Gene Mutations.

Hiroyuki Suzuki, Michitaka Fukuda, Tomotake Shirono, Reiichiro Kondo, Toshimitsu Tanaka, Takashi Niizeki, Jun Akiba, Hironori Koga, Takumi Kawaguchi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hiroyuki SuzukiDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Michitaka FukudaDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Tomotake ShironoDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Reiichiro KondoDepartment of Pathology, Kurume University School of Medicine, Japan.
Toshimitsu TanakaDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Takashi NiizekiDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Jun AkibaDepartment of Pathology, Kurume University School of Medicine, Japan.
Hironori KogaDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.
Takumi KawaguchiDivision of Gastroenterology, Department of Medicine, Kurume University, School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic undifferentiated pleomorphic sarcoma (UPS) is a rare malignant mesenchymal tumor with unclear cancer-related genetic mutations. In a 60-year-old Japanese woman with a rapidly growing, inoperable hepatic UPS, a genetic mutation analysis revealed KRAS and TP53 mutations. Despite initiating hepatic arterial infusion chemotherapy, the tumor continued to grow, and the patient's poor performance status complicated the transition to a phase I KRAS mutation drug trial, leading to death eight months after the symptom onset. A timely genetic mutation analysis may facilitate effective treatment transitions in hepatic UPS despite the lack of established treatments.

Indexed as

Liver NeoplasmsMutationSarcomaTumor Suppressor Protein p53Fatal OutcomeFemaleHumansMiddle AgedProto-Oncogene Proteins p21(ras)KRAS protein, humanProto-Oncogene Proteins p21(ras)TP53 protein, humanTumor Suppressor Protein p53cancer genomic medicinecancer-related gene mutationhepatic undifferentiated pleomorphic sarcomaKRASTP53

Identifiers

PMID39522997
PMCPMC12222998

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.