Evidence map›Paper›PMID 39522768›Full record

ArticleJournal of substance use and addiction treatment2025

The phenotype of recovery XII: A reinforcer pathology perspective on associations between delay discounting and pain catastrophizing in substance use disorder recovery.

Candice L Dwyer, William H Craft, Yu-Hua Yeh, Daniel A R Cabral, Liqa N Athamneh, Allison N Tegge, Jeffrey S Stein, Warren K Bickel

Abstract read
In one paragraph

Article in Journal of substance use and addiction treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Candice L DwyerFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, United States of America; Department of Psychology, Virginia Tech, Blacksburg, VA, United States of America.
William H CraftFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, United States of America.
Yu-Hua YehPsychology Department, Illinois College, Jacksonville, IL, United States of America.
Daniel A R CabralFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, United States of America.
Liqa N AthamnehFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, United States of America.
Allison N TeggeDepartment of Statistics, Virginia Tech, Blacksburg, VA, United States of America. Electronic address: ategge@vt.edu.
Jeffrey S SteinFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, United States of America.
Warren K BickelFralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, United States of America. Electronic address: wkbickel@vtc.vt.edu.

Funding

Longitudinal Study of Recovery: Psychosocial Functioning, Relapse, and Neuro-Behavioral MarkersR01AA029135 · NIAAA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Jungmeen Kim-Spoon, Allison N Tegge · 2022 to 2026
$3.5M
Testing Reinforcer Pathology: Mechanisms and Interventions to Change Alcohol ValuationR01AA027381 · NIAAA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LACONTE, STEPHEN M · 2019 to 2023
$3.5M
NIAAA NIH HHS R01 AA027381NIAAA NIH HHS R01 AA029135
6 · The paper itself

Abstract

backgroundSubstance use disorder (SUD) and pain are highly comorbid conditions and several pain indices (e.g., pain intensity) are associated with an increased risk of relapse. However, the cognitive-emotional experience of pain (i.e., pain catastrophizing) is understudied in SUD recovery. Further, how the association between pain catastrophizing and delay discounting - a posited biomarker of addiction, impacts multidimensional aspects of SUD recovery, including remission and quality of life (QOL), has yet to be examined.

methodsIndividuals (n = 170) in SUD recovery reporting pain were asked about their chronic pain status, completed the Brief Pain Inventory, the Pain Catastrophizing Scale, an Adjusting Amount Delay Discounting Task, and the World Health Organization QOL-BREF scale. Univariate logistic and linear regressions examined associations between delay discounting and several pain indices with remission and QOL. Mediation analyses were investigated whether pain catastrophizing mediates the relationship between delay discounting and 1) sustained remission and 2) QOL.

resultsSignificant negative associations were found between delay discounting (p < .001) and pain catastrophizing (p = .001) with sustained remission. Pain catastrophizing significantly mediated the relationship between delay discounting and physical QOL (p = .044), psychological QOL (p = .009), social (p = .018), and environmental QOL (p = .014). Pain catastrophizing did not mediate the relationship between DD and sustained remission.

conclusionIndividuals with greater DD exhibited greater pain catastrophizing, contributing to poorer QOL in SUD recovery. Our findings support that a Reinforcer Pathology framework is useful to understanding the cognitive-emotional experience of pain within the context of SUD recovery. Interventions that target both delay discounting and maladaptive cognitive and emotional responses to pain may lessen the negative impact of pain on SUD recovery and improve SUD outcomes.

Indexed as

CatastrophizationChronic PainDelay DiscountingSubstance-Related DisordersAdultFemaleHumansMaleMiddle AgedPain MeasurementPhenotypeQuality of LifeYoung AdultDelay discountingPain catastrophizingQuality of lifeRecoverySubstance use disorder

Identifiers

PMID39522768
PMCPMC11801409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.