Evidence map›Paper›PMID 39522628›Full record

ArticleActa biomaterialia2025

Decellularized porcine dermal hydrogel enhances implant-based wound healing in the setting of irradiation.

Lillian DeCostanza, Graham M Grogan, Anthony C Bruce, Corrina M Peachey, Evan A Clark, Kristen Atkins, Tina Tylek, Michael D Solga, Kara L Spiller, Shayn M Peirce and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lillian DeCostanzaDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Graham M GroganDepartment of Plastic Surgery, University of Virginia, Charlottesville, VA, USA.
Anthony C BruceDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Corrina M PeacheyDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Evan A ClarkDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Kristen AtkinsDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
Tina TylekSchool of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.
Michael D SolgaFlow Cytometry Core Facility, University of Virginia, Charlottesville, VA, USA.
Kara L SpillerSchool of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.
Shayn M PeirceDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Christopher A CampbellDepartment of Plastic Surgery, University of Virginia, Charlottesville, VA, USA.
Patrick S CottlerDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; Department of Plastic Surgery, University of Virginia, Charlottesville, VA, USA; Department of Otolaryngology, University of Virginia, Charlottesville, VA, USA. Electronic address: psc5d@uvahealth.org.

Funding

Understanding and Controlling Macrophage Behavior in AngiogenesisR01HL130037 · NHLBI · DREXEL UNIVERSITY · PI SPILLER, KARA LORRAINE · 2016 to 2024
$4.7M
NHLBI NIH HHS R01 HL130037
6 · The paper itself

Abstract

Acellular Dermal Matrix (ADM) provides mechanical and soft tissue support in implant-based breast reconstruction, and has shown to modulate the healing response. However, skin flap necrosis, edema, and previous radiation therapy can hinder ADM integration. Effective biomaterial integration requires regulating the immune response, fibrosis, and adipocyte-driven functionalization. Extracellular matrix (ECM) hydrogels have demonstrated utility in tissue regeneration, and decreasing inflammation and fibrosis in various tissues. Therefore, we hypothesized that a Decellularized Porcine Dermal (DPD) hydrogel to support ADM integration would prevent excessive fibrosis, regulate the macrophage response, and promote adipogenesis. Exploration of DPD hydrogel during ADM implantation in mice (healthy and radiated) revealed long-term effects of irradiation on implant wound healing. DPD hydrogel rescued radiation-induced fibrosis, restoring capsule thickness of healthy mice, and did not increase the fibroblast migration into the ADM. As a modulating soft tissue filler, DPD hydrogel also promoted adipocyte infiltration in healthy and irradiated mice. Detailed macrophage analysis showed that radiation led to the increase in pro-inflammatory, transition, and reparative markers. Despite relatively subtle effects on individual macrophage phenotype markers, multidimensional flow cytometry analysis revealed that DPD hydrogel temporally regulated two subpopulations. he presence of DPD resulted in significantly reduced CD9

Indexed as

Acellular DermisHydrogelsWound HealingAnimalsDecellularized Extracellular MatrixFemaleFibrosisMacrophagesMiceMice, Inbred C57BLSwineDecellularized Extracellular MatrixHydrogelsDecellularized dermisExtracellular matrix hydrogelFibrosisImplant- based breast reconstructionRadiation

Identifiers

PMID39522628
PMCPMC11659024

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.