Evidence map›Paper›PMID 39522453›Full record

ReviewCurrent opinion in immunology2024

Epithelial-immune interactions govern type 2 immunity at barrier surfaces.

Alejandra Lopez Espinoza, Tighe Christopher, Elia D Tait Wojno

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alejandra Lopez EspinozaDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Tighe ChristopherDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA.
Elia D Tait WojnoDepartment of Immunology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: siekhaus@ucla.edu.

Funding

Role of the prostaglandin D2 receptor CRTH2 in helminth-induced type 2 inflammation in the intestine.R01AI130379 · NIAID · UNIVERSITY OF WASHINGTON · PI Elia D Tait Wojno · 2017 to 2026
$3.5M
Prostaglandin D2 and its receptor CRTH2 regulate intestinal inflammation and homeostasisR01DK134410 · NIDDK · UNIVERSITY OF WASHINGTON · PI Elia D Tait Wojno · 2023 to 2026
$2.0M
NIAID NIH HHS R01 AI130379NIDDK NIH HHS R01 DK134410
6 · The paper itself

Abstract

Allergic diseases are acute and chronic inflammatory conditions resulting from disproportionate responses to environmental stimuli. Affecting approximately 40% of the global population, these diseases significantly contribute to morbidity and increasing health care costs. Allergic reactions are triggered by pollen, house dust mites, animal dander, mold, food antigens, venoms, toxins, and drugs. This review explores the pivotal role of the epithelium in the skin, lungs, and gastrointestinal tract in regulating the allergic response and delves into the mechanisms of tissue-specific epithelial-immune interactions in this context, with recent advances highlighting their roles in the initiation, elicitation, and resolution phases of allergy. Understanding these intricate interactions at epithelial barriers is essential for developing targeted therapies to manage and treat allergic diseases.

Indexed as

HypersensitivityAllergensAnimalsEpitheliumHumansSkinTh2 CellsAllergens

Identifiers

PMID39522453
PMCPMC11734749

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.