Evidence map›Paper›PMID 39522116›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2024

Investigation of the ability of 3-((4-chloro-6-methyl pyrimidin-2-yl)amino) isobenzofuran-1(3H)-one to bind to double-stranded deoxyribonucleic acid.

Pelin Şenel, Abdullah Al Faysal, Zeynep Yilmaz, Taner Erdoğan, Mustafa Odabaşoğlu, Ayşegül Gölcü

Abstract read
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In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pelin ŞenelFaculty of Sciences and Letters, Department of Chemistry, Istanbul Technical University, Istanbul, 34469, Turkey.
Abdullah Al FaysalFaculty of Sciences and Letters, Department of Chemistry, Istanbul Technical University, Istanbul, 34469, Turkey.
Zeynep YilmazFaculty of Engineering, Chemical Engineering Department, Pamukkale University, Denizli, Turkey.
Taner ErdoğanDepartment of Chemistry and Chemical Processing Technologies, Kocaeli University, Kocaeli Vocational High School, Kocaeli, Turkey.
Mustafa OdabaşoğluChemistry Technology Programme, Pamukkale University, Kinikli, Denizli, 20070, Turkey.
Ayşegül GölcüFaculty of Sciences and Letters, Department of Chemistry, Istanbul Technical University, Istanbul, 34469, Turkey. aysegulgolcu@itu.edu.tr.ORCID http://orcid.org/0000-0001-5228-1682

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phthalides represent a notable category of secondary metabolites that are prevalent in various plant species, certain fungi, and liverworts. The significant pharmacological properties of these compounds have led to the synthesis of a novel phthalide derivative. The current study focuses on investigating the binding interactions of a newly synthesized 3-substituted phthalide derivative, specifically 3-((4-chloro-6-methyl pyrimidine-2-yl)amino) isobenzofuran-1(3H)-one (Z11), with double-stranded deoxyribonucleic acid (dsDNA). Research in the pharmaceutical and biological fields aimed at developing more potent DNA-binding agents must take into account the mechanisms by which these newly synthesized compounds interact with DNA. This investigation seeks to explore the binding dynamics between dsDNA and our compound through a variety of analytical techniques, such as electrochemistry, UV spectroscopy, fluorescence spectroscopy, and thermal denaturation. The binding constant (K

Indexed as

BenzofuransDNABinding SitesDensity Functional TheoryHydrogen BondingBenzofuransDNADouble strain deoxyribonucleic acid (dsDNA)Molecular dockingPhthalideSpectroscopyThermal denaturationVoltammetry

Identifiers

PMID39522116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.