ArticleInternational ophthalmology2024
Exploring the therapeutic potential: sinomenine and melatonin in alkali-induced corneal burns.
Article in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Feasibility analysis of Sinomenine alleviating fibrosis of filtering bleb after glaucoma filtering surgery: a mini review.Frontiers in medicine · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to investigate the effects of sinomenine and melatonin on corneal alkali burns.
methodsTwenty-seven female Wistar albino rats, aged 3-6 months and weighing 200-300 g, were used in this study. After the induction of general anesthesia, 2 mol/L sodium hydroxide (NaOH) solution was used to create corneal alkali burns in all experimental animals. The rats were divided into three groups: Group C, control group with no additional treatment; Group M, topical melatonin drop group; and Group S, topical sinomenine group. The rats were sacrificed under general anesthesia on the 7th day. Various parameters, including corneal inflammation, neovascularization, epithelialization, epithelial proliferating cell nuclear antigen (PCNA), epithelial inducible nitric oxide synthase (INOS), stromal INOS, and thickness, were evaluated.
resultsThe experiment was completed with 27 rats distributed into three groups of nine rats each. Significant differences were observed between the groups in terms of stromal thickness, inflammation, epithelial iNOS, stromal iNOS, and epithelialization (p = 0.008, p = 0.005, p = 0.020, p = 0.037, and p = 0.000, respectively). The best stromal thickness was observed in Group M. Vascularization, inflammation, epithelial INOS, stromal iNOS, and epithelialization were most effectively reduced in Group S, followed by Group M. Group S outperformed Group C significantly in all these aspects (p = 0.049, p = 0.004, p = 0.015, p = 0.036, p = 0.000, respectively). There was no significant difference between the groups in terms of the epithelial PCNA levels (p = 0.259).
conclusionsThe results suggest that topical sinomenine and melatonin have anti-inflammatory, anti-angiogenic, and reepithelialization effects when applied after alkali burns in rat corneas.
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Registered trials
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