Evidence map›Paper›PMID 39522072›Full record

ReviewMolecular diversity2025

Decarboxylative click cycloaddition: an emerging strategy towards substituted 1,2,3-triazole derivatives.

Manpreet Kaur, Divya Bharti, Vinod Kumar, Praveen Kumar Verma, Rakesh Kumar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manpreet KaurLaboratory of Organic Synthesis and Catalysis, Department of Chemistry, Central University of Punjab, Bathinda, 151401, India.
Divya BhartiLaboratory of Organic Synthesis and Catalysis, Department of Chemistry, Central University of Punjab, Bathinda, 151401, India.
Vinod KumarLaboratory of Organic Synthesis and Catalysis, Department of Chemistry, Central University of Punjab, Bathinda, 151401, India.
Praveen Kumar VermaSchool of Advanced Chemical Sciences, Shoolini University, Solan, Himachal Pradesh, 173229, India.
Rakesh KumarLaboratory of Organic Synthesis and Catalysis, Department of Chemistry, Central University of Punjab, Bathinda, 151401, India. rakesh.kumar@cup.edu.in.

Funding

Council of Scientific and Industrial Research, India 09/1051(14051)/2022-EMR-1University Grants Commission 191620114027
6 · The paper itself

Abstract

1,2,3-triazole is a vital structural motif of various drugs and therapeutic leads, as well as a linker for bioconjugation and molecular recognition. Cu-catalysed click cycloaddition of azides with terminal alkynes (CuAAc) is an important reaction to construct the triazole core. In recent years, various decarboxylative click strategies utilizing alkynoic acids as stable surrogates for low boiling or gaseous alkynes have been developed. For instance, propiolic acid, which is easy to transport, is a safe alternative for flammable gaseous acetylene. In this review article, we have covered the recent development in the decarboxylative click cycloaddition of alkynoic acids with azides leading to the synthesis of diversely substituted triazoles, including monosubstituted, 1,4-disubstituted and fully substituted 1,2,3-triazoles. Various aspects such as mechanistic insights and optimization conditions/role of catalyst are highlighted.

Indexed as

Click ChemistryCycloaddition ReactionTriazolesAlkynesAzidesCatalysisDecarboxylationAlkynesAzidesTriazoles1,2,3-triazoleClick chemistryDecarboxylative cycloadditionHuisgen reaction

Identifiers

PMID39522072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.