Evidence map›Paper›PMID 39521942›Full record

ArticleNPJ precision oncology2024

Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer.

Fangyuan Chen, Sayali Onkar, Jian Zou, Yujia Li, Haley Arbore, Sai Maley, George Tseng, Peter C Lucas, Tullia C Bruno, Dario A A Vignali and 4 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Interplay of Interleukin-1Oncology research · 2026
    Article
  3. Pitfalls in the Histological Diagnosis of Morphologic Variants of Invasive Lobular Carcinoma of the Breast.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Fangyuan ChenDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-9891-4753
Sayali OnkarDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jian ZouDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
Yujia LiDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.
Haley ArboreUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Sai MaleyNational Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA.
George TsengDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-5447-1014
Peter C LucasUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Tullia C BrunoDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Dario A A VignaliDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Julia FoldiUPMC Hillman Cancer Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-7504-867X
Marija BalicUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Adrian V LeeDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. leeav@upmc.edu.ORCID http://orcid.org/0000-0001-9917-514X
Steffi OesterreichDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. oesterreichs@upmc.edu.

Funding

Synergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2015 to 2026
$30.8M
Regulatory T cells and the tumor microenvironmentR35CA263850 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2021 to 2026
$5.4M
Developing and credentialing murine models of ILCR01CA252378 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Adrian V Lee, Steffi Oesterreich · 2021 to 2026
$3.0M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) S10OD028483NCI NIH HHS R01 CA252378NCI NIH HHS R35 CA263850NIAID NIH HHS P01 AI108545
6 · The paper itself

Abstract

Understanding interplay of breast cancer and microenvironment is critical. Here we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER + /HER2- ILCs. We found proliferative subtype associated with increased suppressive immune infiltration, and defined a signature associated with lower proliferative, pro-inflammatory TAM infiltration, and improved survival in ER+ breast cancer. Our work identified genes related to ILC immune microenvironment and prognosis.

Identifiers

PMID39521942
PMCPMC11550424

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.