ArticleScientific reports2024
Human papillomavirus and male infertility correlation analysis following World Health Organization 2021 guidelines.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Urine sample for HPV detection in men: is it a valid and non-invasive diagnostic alternative?Microbiology spectrum · 2026Article
- Unfolding the Semen Microbiota: Implications for Male Infertility.Biomedicines · 2026Review
- The role of m6A modification in spermatogenic dysfunction.Molecular biology reports · 2026Review
- Influence of human papillomavirus on semen parameters and male infertility: a single-center study.JBRA assisted reproduction · 2026Article
- Human Papillomavirus (HPV) and Infertility: A Cross-Sectional Study Exploring Its Prevalence and Effects in Iranian Couples.Health science reports · 2025Article
- Human papillomavirus seminal carriage alters virome diversity and male fertility: a case-control study.Reproductive biology and endocrinology : RB&E · 2025Article
- Human papillomavirus infection in males: implications for fertility, assisted reproductive outcomes, and vaccination strategies.Virology journal · 2025Review
- Effect of human papillomavirus infection on semen quality and assisted reproductive technology outcomes: a prospective observational cohort study.BMC medicine · 2025Observational
- From infection to infertility: a review of the role of human papillomavirus-induced oxidative stress on reproductive health and infertility.European journal of medical research · 2025Review
- A Narrative Review on the Sperm Selection Methods in Assisted Reproductive Technology: Out with the New, the Old Is Better?Journal of clinical medicine · 2025Review
- HPV-51 or HPV-52 Infection Could Impair Sperm Quality in Infertile Patients: A Preliminary Study on Our Experience from North-Western Italy.Tropical medicine and infectious disease · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male infertility is a complex issue influenced by multiple environmental and pathological factors. In this context, the impact of Human papillomavirus (HPV) infection on male fertility remains controversial. The introduction of new WHO 2021 evaluation criteria, included in the 6th ed. of Laboratory Manual for the examination and processing of human semen, i.e. DNA fragmentation index (DFI), slow and rapid progressive motility, could provide additional information about this correlation. 121 semen samples of male partners of HPV-positive women attending In Vitro Fertilization (IVF) were evaluated following WHO 2021 and HPV-DNA test. Comparing HPV-negative and positive samples for rapid and slow progressive motility showed significantly different results (p = 0.0018, p = 0.0004), contrary to what was observed for total progressive motility. Regarding sperm DFI, only high-risk HPV infections affected DNA integrity. In addition, the correlation between the different semen parameters revealed a significant correlation between midpiece morphological defects and rapid progressive motility in the HPV-positive group (rho = 0.43, p = 0.0006). In conclusion, WHO 2021 provides additional information regarding HPV's impact on seminal parameters. The correlation between HPV positivity, midpiece defects and a higher rapid progressive motility opens new research perspectives that may help unravel the issues surrounding the role of HPV in compromising sperm quality.
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