Elaboration of newly synthesized tetrahydrobenzo[b]thiophene derivatives and exploring their antioxidant evaluation, molecular docking, and DFT studies.

Mina G Balamon, Ashraf A Hamed, Eman A El-Bordany, Ahmed E Swilem, Naglaa F H Mahmoud

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Mina G BalamonDepartment of Chemistry, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt. minagirgis@sci.asu.edu.eg.

Ashraf A HamedDepartment of Chemistry, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.

Eman A El-BordanyDepartment of Chemistry, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.

Ahmed E SwilemDepartment of Chemistry, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.

Naglaa F H MahmoudDepartment of Chemistry, Faculty of Science, Ain Shams University, Cairo, 11566, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, 2-amino-6-(tert-butyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitrile (1) was synthesized in excellent yield through gewald reaction in multi components one pot reaction. Compound 1 was utilized as a building block to synthesize a new group of tetrahydro benzo[b] thiophene congeners. The chemical structure of all the novel tetrahydro benzo[b]thiophene derivatives were elucidated through the melting point, elemental analysis, FT-IR,

Indexed as

AntioxidantsDensity Functional TheoryMolecular Docking SimulationThiophenesAscorbic AcidHumansKelch-Like ECH-Associated Protein 1Molecular StructureStructure-Activity RelationshipAntioxidantsAscorbic AcidKelch-Like ECH-Associated Protein 1Thiophenes2-amino thiophene-3-carbonitrileAntioxidantDFTDocking

Identifiers

PMID39521808

DOI10.1038/s41598-024-74275-x

PMCPMC11550804

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.