Evidence map›Paper›PMID 39521792›Full record

ReviewNature communications2024

Next-generation rapid phenotypic antimicrobial susceptibility testing.

Grace Reszetnik, Keely Hammond, Sara Mahshid, Tamer AbdElFatah, Dao Nguyen, Rachel Corsini, Chelsea Caya, Jesse Papenburg, Matthew P Cheng, Cedric P Yansouni

Erratum issuedAbstract readReview
In one paragraph

Review in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Metabolism-Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  10. Point of care antimicrobial susceptibility testing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Grace ReszetnikDepartment of Bioengineering, Faculty of Engineering, McGill University, Montreal, Quebec, Canada.
Keely HammondDivisions of Infectious Diseases and Medical Microbiology, McGill University Health Centre, Montreal, Quebec, Canada.
Sara MahshidDepartment of Bioengineering, Faculty of Engineering, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-4203-819X
Tamer AbdElFatahDepartment of Bioengineering, Faculty of Engineering, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-4141-2442
Dao NguyenMcGill Antimicrobial Resistance Centre, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-4012-5441
Rachel CorsiniResearch, Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Chelsea CayaResearch, Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Jesse PapenburgResearch, Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Matthew P ChengDivisions of Infectious Diseases and Medical Microbiology, McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0002-4867-2063
Cedric P YansouniDivisions of Infectious Diseases and Medical Microbiology, McGill University Health Centre, Montreal, Quebec, Canada. cedric.yansouni@mcgill.ca.ORCID 0000-0002-4765-3469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Slow progress towards implementation of conventional clinical bacteriology in low resource settings and strong interest in greater speed for antimicrobial susceptibility testing (AST) more generally has focused attention on next-generation rapid AST technologies. In this Review, we systematically synthesize publications and submissions to regulatory agencies describing technologies that provide phenotypic AST faster than conventional methods. We characterize over ninety technologies in terms of underlying technical innovations, technology readiness level, extent of clinical validation, and time-to-results. This work provides a guide for technology developers and clinical microbiologists to understand the rapid phenotypic AST technology landscape, current development pipeline, and AST-specific validation milestones.

Indexed as

Anti-Bacterial AgentsBacteriaMicrobial Sensitivity TestsPhenotypeBacterial InfectionsHumansAnti-Bacterial Agents

Identifiers

PMID39521792
PMCPMC11550857

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.