Evidence map›Paper›PMID 39521758›Full record

ArticleScientific reports2024

Molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae in Gauteng South Africa.

Kafilat T Salvador-Oke, Johann D D Pitout, Gisele Peirano, Kathy-Anne Strydom, Chanel Kingsburgh, Marthie M Ehlers, Arshad Ismail, Faustinos T Takawira, Marleen M Kock

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Phenotypic and genome-based characterization ofFrontiers in microbiology · 2026
    Article
  7. Genomic Characterization ofOpen forum infectious diseases · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kafilat T Salvador-OkeDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Johann D D PitoutDepartment of Pathology and Laboratory Medicine, Cummings School of Medicine, University of Calgary, Calgary, Canada.
Gisele PeiranoDepartment of Pathology and Laboratory Medicine, Cummings School of Medicine, University of Calgary, Calgary, Canada.
Kathy-Anne StrydomTshwane Academic Division, Department of Medical Microbiology, National Health Laboratory Service, Pretoria, South Africa.
Chanel KingsburghTshwane Academic Division, Department of Medical Microbiology, National Health Laboratory Service, Pretoria, South Africa.
Marthie M EhlersDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Arshad IsmailSequencing Core Facility, National Institute for Communicable Diseases a Division of the National Health Laboratory Service, Johannesburg, 2131, South Africa.
Faustinos T TakawiraResearch Circle Trust, Harare, Zimbabwe.
Marleen M KockDepartment of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. marleen.kock@up.ac.za.

Funding

NATIONAL RESEARCH FOUNDATION (NRF) South Africa 129376
6 · The paper itself

Abstract

Klebsiella pneumoniae multidrug-resistant (MDR) high-risk clones drive the spread of antimicrobial resistance (AMR) associated infections, resulting in limited therapeutic options. This study described the genomic characteristics of K. pneumoniae MDR high-risk clones in Gauteng, South Africa. Representative carbapenem-resistant [K. pneumoniae carbapenemase (KPC)-2, New-Delhi metallo-beta (β)-lactamase (NDM)-1, oxacillinase (OXA)-181, OXA-232, OXA-48, Verona integron-encoded metallo-β-lactamase (VIM)-1] K. pneumoniae isolates (n = 22) obtained from inpatient and outpatient's urine (n = 9) and inpatients rectal carriage (n = 13) were selected for short-read whole genome sequencing. Klebsiella pneumoniae population include sequence type (ST)-307 (n = 3), ST2497 (n = 5) and ST17 (n = 4). The ST17 strains were exclusively obtained from rectal screening. Ten isolates co-harboured carbapenemase genes including β-lactamase gene encoding KPC-2 + OXA-181, NDM-1 + OXA-48 and NDM-1 + OXA-181. One ST307 isolate (UP-KT-73CKP) co-harboured three carbapenemase genes (bla

Indexed as

Bacterial Proteinsbeta-LactamasesKlebsiella InfectionsKlebsiella pneumoniaeMolecular EpidemiologyAnti-Bacterial AgentsDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsSouth AfricaWhole Genome SequencingAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasescarbapenemasebla OXA-181Carbapenemase-producing Klebsiella pneumoniaeHigh-risk clonesIncX3ST307Virulence determinants

Identifiers

PMID39521758
PMCPMC11550437

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.