Evidence map›Paper›PMID 39520981›Full record

ArticleMolecular cell2024

VPS4A is the selective receptor for lipophagy in mice and humans.

Debajyoti Das, Mridul Sharma, Deepanshi Gahlot, Shervin S Nia, Chandrima Gain, Matthew Mecklenburg, Z Hong Zhou, Mathieu Bourdenx, Lipi Thukral, Nuria Martinez-Lopez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Lipophagy and lipid droplets in neurodegeneration.Trends in pharmacological sciences · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Where and how do mammalian cells shape autophagosomes?The Journal of biological chemistry · 2026
    Review
  10. Article
  11. ESCRT-III function in membrane fission and repair.Nature reviews. Molecular cell biology · 2026
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Debajyoti DasDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Mridul SharmaDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Deepanshi GahlotCSIR-Institute of Genomics and Integrative Biology, New Delhi, India; Academy of Scientific and Innovative Research, Ghaziabad, India.
Shervin S NiaCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Chandrima GainDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Matthew MecklenburgCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Z Hong ZhouCalifornia NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Mathieu BourdenxUK Dementia Research Institute, London, UK; UCL Queen Square Institute of Neurology, London, UK.
Lipi ThukralCSIR-Institute of Genomics and Integrative Biology, New Delhi, India; Academy of Scientific and Innovative Research, Ghaziabad, India.
Nuria Martinez-LopezDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Comprehensive Liver Research Center at University of California, Los Angeles, Los Angeles, CA, USA.
Rajat SinghDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Comprehensive Liver Research Center at University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: rajatsingh@mednet.ucla.edu.

Funding

Role of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MACIAN, FERNANDO · 2009 to 2024
$36.2M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Hyptothalamic autophagy and metabolic regulation in agingRF1AG043517 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGH, RAJAT · 2019 to 2019
$2.1M
Circadian Mechanisms of Diabetes Prevention in Aged miceR01AG065985 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGH, RAJAT · 2019 to 2023
$2.1M
Molecular regulation of gut lipid metabolism by mTOR and autophagy proteinsR01DK123327 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGH, RAJAT · 2019 to 2023
$1.9M
Nutrient signaling at ER-Mitochondrial contacts and age-related mitochondrial dysfunctionR01AG082761 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Rajat Singh · 2023 to 2026
$1.6M
NIA NIH HHS P01 AG031782NIA NIH HHS R01 AG065985NIA NIH HHS R01 AG082761NIA NIH HHS RF1 AG043517NIDDK NIH HHS R01 DK123327NIGMS NIH HHS T32 GM145388
6 · The paper itself

Abstract

Lipophagy is a ubiquitous mechanism for degradation of lipid droplets (LDs) in lysosomes. Autophagy receptors selectively target organelles for lysosomal degradation. The selective receptor for lipophagy remains elusive. Using mouse liver phosphoproteomics and human liver transcriptomics, we identify vacuolar-protein-sorting-associated protein 4A (VPS4A), a member of a large family AAA+ ATPases, as a selective receptor for lipophagy. We show that phosphorylation of VPS4A on Ser

Indexed as

ATPases Associated with Diverse Cellular ActivitiesAutophagyFatty LiverLiverAnimalsEndosomal Sorting Complexes Required for TransportHumansLipid DropletsLysosomesMaleMiceMice, Inbred C57BLMicrotubule-Associated ProteinsPhosphorylationVacuolar Proton-Translocating ATPasesATPases Associated with Diverse Cellular ActivitiesEndosomal Sorting Complexes Required for TransportMicrotubule-Associated ProteinsVacuolar Proton-Translocating ATPasesVPS4A protein, humanautophagyhumanlipid dropletlipophagyliverlysosomeMASLDphosphorylationreceptorVPS4A

Identifiers

PMID39520981
PMCPMC11631789

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.