Evidence map›Paper›PMID 39520689›Full record

ArticleThe Journal of physiology2025

Regional cerebral perfusion and sympathetic activation during exercise in hypoxia and hypercapnia: preliminary insight into 'Cushing's mechanism'.

Hsuan-Yu Wan, Kanokwan Bunsawat, Catherine L Jarrett, Katherine L Shields, Angela V Bisconti, Joshua C Weavil, Markus Amann

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hsuan-Yu WanDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-8853-8451
Kanokwan BunsawatGeriatric Research, Education, and Clinical Centre, Veterans Affairs Medical Centre, Salt Lake City, UT, USA.
Catherine L JarrettGeriatric Research, Education, and Clinical Centre, Veterans Affairs Medical Centre, Salt Lake City, UT, USA.
Katherine L ShieldsGeriatric Research, Education, and Clinical Centre, Veterans Affairs Medical Centre, Salt Lake City, UT, USA.
Angela V BiscontiGeriatric Research, Education, and Clinical Centre, Veterans Affairs Medical Centre, Salt Lake City, UT, USA.
Joshua C WeavilGeriatric Research, Education, and Clinical Centre, Veterans Affairs Medical Centre, Salt Lake City, UT, USA.
Markus AmannDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-4012-8880

Funding

Role of Sensory Neurons in Human Cardiovascular DiseaseR01HL116579 · NHLBI · UNIVERSITY OF UTAH · PI AMANN, MARKUS · 2013 to 2021
$3.4M
Autonomic Dysfunction in Patients with HFpEFR01HL162856 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2023 to 2026
$2.7M
Cardiovascular and neuromuscular issues in chronic painR01HL170007 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2024 to 2026
$2.3M
Efficacy of exercise training in patients with HFpEFI01RX003343 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI MARKUS AMANN · 2021 to 2026
–
NHLBI NIH HHS R01 HL116579NHLBI NIH HHS R01 HL162856NHLBI NIH HHS R01 HL170007RRD VA I01 RX003343RRD VA IK2 RX003670
6 · The paper itself

Abstract

We examined the interactive influence of hypoxia and exercise, and hypercapnia and exercise, on regional cerebral perfusion and sympathetic activation. Twenty healthy young adults (seven women) completed study trials including (1) rest in normoxia (

Indexed as

Cerebrovascular CirculationExerciseHypercapniaHypoxiaSympathetic Nervous SystemAdultFemaleHumansMaleYoung Adultastrocyteautonomic nervous systemcerebral blood flowcerebral oxygen deliverymuscle sympathetic nerve activity

Identifiers

PMID39520689
PMCPMC12062350

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.