Evidence map›Paper›PMID 39520656›Full record

ArticleAdvances in therapy2025

Prognostic Impact of Neutropenia Recovery and G-CSF Use in Onco-Hematological Neutropenic Patients Admitted to Intensive Care Unit for Acute Respiratory Failure: A Retrospective, Real World Analysis.

Carolina Secreto, Bastien Morel, Magali Bisbal, Wulfran Pennors, Camille Pouliquen, Jauffrey Albanese, Marc Leone, Marco Cerrano, Luca Servan, Frédéric Gonzalez and 4 more

Abstract read
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In one paragraph

Article in Advances in therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Carolina SecretoDivision of Hematology, Department of Oncology, A.O.U. Città Della Salute e della Scienza di Torino, Turin, Italy. carolina.secreto@gmail.com.
Bastien MorelDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Magali BisbalDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Wulfran PennorsDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Camille PouliquenDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Jauffrey AlbaneseDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Marc LeoneDepartment of Anesthesiology and Intensive Care Medicine, Nord Hospital, Assistance Publique Hôpitaux Universitaires de Marseille, Aix Marseille University, Marseille, France.
Marco CerranoDivision of Hematology, Department of Oncology, A.O.U. Città Della Salute e della Scienza di Torino, Turin, Italy.
Luca ServanDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Frédéric GonzalezDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Marion FaucherDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Laurent Chow-ChineDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Antoine SanniniDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.
Djamel MokartDepartment of Anesthesiology and Intensive Care Unit, Institut Paoli-Calmettes, Marseille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe effect of neutropenia and the use of granulocyte colony-stimulating factor (G-CSF) in critically ill patients with cancer are controversial, notably in those with lung injury. Neutropenia recovery can be associated with an acute respiratory failure (ARF) requiring intensive care unit (ICU) admission, especially when G-CSF is administered.

methodsIn a single-center retrospective study, we evaluated (1) the effect of neutropenia recovery on the 90-day mortality and (2) the impact of G-CSF use on the outcome of patients with cancer and neutropenia with ARF admitted to the ICU.

resultsAmong 1098 screened patients, 152 were neutropenic at ICU admission. The 90-day mortality was 44.7%. Factors independently associated with the 90-day mortality were invasive mechanical ventilation, ground-glass opacities and nodules on computed tomography scans, a disease in progression and the Simplified Acute Physiology Score (SAPS II) at ICU admission. The lack of neutropenia recovery during the ICU stay was associated with the 90-day mortality. Using G-CSF had no effect on the 90-day mortality or the neutropenia duration, but the PaO

conclusionOur study suggests that neutropenia recovery was associated with survival in critically ill patients with cancer and neutropenia with ARF admitted to ICU, and the G-CSF could worsen the respiratory parameters.

Indexed as

Granulocyte Colony-Stimulating FactorNeoplasmsNeutropeniaRespiratory InsufficiencyAdultAgedFemaleHumansIntensive Care UnitsMaleMiddle AgedPrognosisRespiration, ArtificialRetrospective StudiesGranulocyte Colony-Stimulating Factor90-Day mortalityAcute respiratory failureG-CSFIntensive care unitNeutropenia recovery

Identifiers

PMID39520656

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.