ArticleAging clinical and experimental research2024
Association between frailty status and risk of chronic lung disease: an analysis based on two national prospective cohorts.
Article in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Gut microbiota alpha-diversity and taxonomic differences between maintenance hemodialysis patients and healthy controls: a systematic review and meta-analysis.International urology and nephrology · 2026Article
- Frailty transitions and the risk of multisystem burden of chronic disease: a prospective cohort study in China.Archives of public health = Archives belges de sante publique · 2026Article
- Association between frailty status and depression among older adults: panel data analysis of three longitudinal cohort studies.BMC public health · 2026Article
- Association between frailty transitions and chronic lung disease incidence: findings from four national cohort studies.BMC public health · 2025Article
- Methodological concerns on the association between frailty and chronic lung disease.Aging clinical and experimental research · 2025Article
- Association of atherogenic index of plasma trajectory with the incidence of cardiovascular disease over a 12-year follow-up: findings from the ELSA cohort study.Cardiovascular diabetology · 2025Article
- The association between speech impairments and depression in Chinese adults aged 45 and older: insights from the CHARLS database.BMC psychiatry · 2025Article
- Frailty status and chronic lung disease: a contextual and methodological discussion.Aging clinical and experimental research · 2025Article
- Association between the dietary index for gut microbiota and frailty: the mediating role of body mass index.Frontiers in nutrition · 2025Article
- Associations of sarcopenic obesity with chronic lung disease and peak expiratory flow in middle-aged and older adults: A cohort study based on CHARLS and ELSA.Chronic respiratory diseaseArticle
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Abstract
backgroundThe association between the frailty index (FI) and the risk of chronic lung diseases (CLDs) remains unexplored, warranting further research. METHODS AND MATERIALS: This study investigated the relationship between FI and CLD risk using data from the China Health and Retirement Longitudinal Study (CHARLS) and English Longitudinal Study of Ageing (ELSA), comprising a combined sample of 9642 individuals. Propensity score weighting was used to ensure similar distribution of covariates across FI groups. The Wilcoxon rank-sum test was used to analyze differences in FI scores between groups with and without CLD. Kaplan-Meier curves and Cox regression analysis were employed to explore the association between frailty status and CLD incidence, with sensitivity analyses conducted for validation.
resultsHigher FI scores were significantly associated with increased CLD risk in both cohorts (p < .05). Kaplan-Meier survival and Cox regression analyses indicated that frail individuals have a significantly elevated risk of CLD compared to robust individuals, particularly in certain subgroups (e.g., female) within the CHARLS cohort (p < .05). The ELSA cohort yielded similar results (p < .05), affirming FI as a strong predictor of CLD. Additional risk factors identified included age, smoking, and unmarried status (p < .05). Frail individuals consistently exhibited the highest risk in both cohorts (CHARLS HR = 1.54, p = .003; ELSA HR = 6.64, p < .001). The sensitivity analysis did not substantially alter the significant associations.
conclusionThese findings emphasize the critical role of frailty in the development of CLD, suggesting that targeted interventions could reduce CLD risk.
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