Evidence map›Paper›PMID 39520616›Full record

ArticleMolecular diversity2025

Design, synthesis and evaluation of benzothiazole-derived phenyl thioacetamides as dual inhibitors of monoamine oxidases and cholinesterases.

Sandeep Kumar, Rangan Mitra, Senthil Raja Ayyannan

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sandeep KumarPharmaceutical Chemistry Research Laboratory II, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India.ORCID http://orcid.org/0000-0002-0826-6546
Rangan MitraPharmaceutical Chemistry Research Laboratory II, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India.ORCID http://orcid.org/0000-0003-0370-8883
Senthil Raja AyyannanPharmaceutical Chemistry Research Laboratory II, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, 221005, India. asraja.phe@iitbhu.ac.in.ORCID http://orcid.org/0000-0002-6008-4571

Funding

Ministry of Education, India STARS 1/583
6 · The paper itself

Abstract

A series of rationally designed benzothiazole-derived thioacetamides was synthesized and investigated for monoamine oxidases (MAO-A and MAO-B) and cholinesterases (AChE and BChE) inhibition properties. The tested compounds 18-31 inhibited MAO-A and MAO-B in the micromolar to nanomolar range and AChE in the submicromolar range. Compound 28 was identified as the most potent MAO-A inhibitor with an IC

Indexed as

AcetamidesBenzothiazolesCholinesterase InhibitorsDrug DesignMonoamine OxidaseMonoamine Oxidase InhibitorsAcetylcholinesteraseButyrylcholinesteraseHumansMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAcetamidesAcetylcholinesterasebenzothiazoleBenzothiazolesButyrylcholinesteraseCholinesterase InhibitorsMonoamine OxidaseMonoamine Oxidase InhibitorsAntioxidantBenzothiazoleCholinesterasesMetal chelationMolecular dockingMonoamine oxidasesThioacetamide

Identifiers

PMID39520616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.