Evidence map›Paper›PMID 39520610›Full record

ArticleDiscover oncology2024

Asparaginase and isoaspartyl peptidase 1 RNA interference suppresses the growth of nasopharyngeal carcinoma cells.

Bo Feng, Yingying Pei, Weiwei Zhang, Qi Zheng, Yan Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bo Feng *Department of Otorhinolaryngology, The First Affiliated Hospital of Ningbo University, No.56 Liuting Street, Ningbo, 315020, Zhejiang, China. 2274845227@qq.com.
Yingying Pei *Department of Otorhinolaryngology, The First Affiliated Hospital of Ningbo University, No.56 Liuting Street, Ningbo, 315020, Zhejiang, China.
Weiwei ZhangDepartment of Otorhinolaryngology, The First Affiliated Hospital of Ningbo University, No.56 Liuting Street, Ningbo, 315020, Zhejiang, China.
Qi ZhengDepartment of Otorhinolaryngology, The First Affiliated Hospital of Ningbo University, No.56 Liuting Street, Ningbo, 315020, Zhejiang, China.
Yan ZhouDepartment of Otorhinolaryngology, The First Affiliated Hospital of Ningbo University, No.56 Liuting Street, Ningbo, 315020, Zhejiang, China.

Funding

Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2020KY847Natural Science Foundation of Ningbo Science and Technology Bureau 2022J234
6 · The paper itself

Abstract

Nasopharyngeal carcinoma (NPC) is one of the common malignant tumors, and its pathogenesis has not been fully clarified. This study aims to explore the impact of RNA interference on the growth and invasion of NPC cells. Asparaginase and isoaspartyl peptidase 1 (ASRGL1)-short hairpin(sh) RNA expressing lentivirus was used to investigate the effect of ASRGL1 knockdown on NPC cells (C666-1 and SUN-1). The target shASRGL1 gene was determined by mRNA and protein expression in nasopharyngeal carcinoma cells; nasopharyngeal carcinoma cell proliferation viability, migration, invasion, apoptosis, ATP levels, and oxidative stress were examined. The results found that ASRGL1 was found to be highly expressed in NPC tissues and cell lines. shASRGL1 exhibited a high gene expression knockdown efficiency, downregulated the ASRGL1 protein expression in the nasopharyngeal carcinoma cells, suppressed proliferation viability of transfected nasopharyngeal carcinoma cells, inhibited their migration and invasion and ATP levels, promoted nasopharyngeal carcinoma cell apoptosis, ROS, and ferroptosis. shASRGL1 plays a role in protecting against NPC cell growth and invasion.

Indexed as

Asparaginase and isoaspartyl peptidase 1Nasopharyngeal carcinoma cellRNA interference

Identifiers

PMID39520610
PMCPMC11550296

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.