Evidence map›Paper›PMID 39520594›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Delivery of Stem Cell-Rejuvenating Compounds via Subcutaneous Osmotic Pumps.

Sen Zhang, Sandra Pinho

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sen ZhangDepartment of Pharmacology & Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Sandra PinhoDepartment of Pharmacology & Regenerative Medicine, University of Illinois at Chicago, Chicago, IL, USA. spinho@uic.edu.

Funding

Mechanisms of hematopoietic stem cell engraftmentR01HL162584 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Sandra Pinho · 2022 to 2026
$2.2M
NHLBI NIH HHS R01 HL162584
6 · The paper itself

Abstract

Aging is widely regarded as an irreversible physiological process throughout the mammalian lifespan, characterized by functional tissue deterioration and increased disease incidence. One hallmark of mammalian aging is reduced tissue regeneration, primarily attributed to the declining function of tissue-specific stem cells. In recent years, various strategies aimed at rejuvenating stem cells through drug-delivery systems have been extensively explored. Here we describe a method for the long-term, controlled, systemic delivery of drugs using subcutaneous implantations of osmotic pumps.

Indexed as

Drug Delivery SystemsRejuvenationStem CellsAnimalsHumansMiceOsmosisControlled release methodLong-term administrationOsmotic pumpRejuvenationSystemic

Identifiers

PMID39520594
PMCPMC12064785

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.