Evidence map›Paper›PMID 39520585›Full record

ArticleInternational ophthalmology2024

Klotho relieves H

Yiling Zhou, Tieying Zhao

Abstract read
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In one paragraph

Article in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yiling ZhouDepartment of Fundus Disease, Shenzhen Huaxia Eye Hospital, Lianhua Road 2032-1, Shenzhen, 518000, China.
Tieying ZhaoDepartment of Fundus Disease, Shenzhen Huaxia Eye Hospital, Lianhua Road 2032-1, Shenzhen, 518000, China. Tying_Zh@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-related cataract (ARC) is a common eye disease and represents a common contributing factor to visual damage and loss. Klotho is a longevity gene and has been reported to participate in aging-related disorders. This work aims to investigate the potential role of klotho in ARC.

methodsIn human lens epithelial cells (HLECs) induced by varying concentrations of hydrogen peroxide (H

resultsKlotho expression was decreased in HLECs induced by increasing concentrations of H

conclusionsTo sum up, klotho may down-regulate NOX4 to protect against H

Indexed as

ApoptosisCell SurvivalEpithelial CellsGlucuronidaseHydrogen PeroxideKlotho ProteinsLens, CrystallineNADPH Oxidase 4Oxidative StressBlotting, WesternCataractCells, CulturedFlow CytometryHumansMembrane Potential, MitochondrialReactive Oxygen SpeciesGlucuronidaseHydrogen PeroxideKlotho ProteinsKL protein, humanNADPH Oxidase 4NOX4 protein, humanReactive Oxygen SpeciesHuman lens epithelial cellsKlothoNOX4Oxidative stressSenescence

Identifiers

PMID39520585

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.