Evidence map›Paper›PMID 39520556›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

In vitro, in vivo and in silico anticancer activity and toxicity of Usnic acid extracted from the mycobiont culture of Usnea baileyi.

Murugan Mariraj, Mallikarjun Gundappa, Shanmugam Velayuthaprabhu, Kamal Shah, Ponmurugan Ponnuchamy, Suresh Kumar Mendem, P Shivakumar Singh, Nagendra Singh Chauhan

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Usnic Acid and Its Topical Use-A Concise Review.Molecules (Basel, Switzerland) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Murugan MarirajDepartment of Botany, Sri Kaliswari College, Sivakasi, Virudhunagar, Dist-626130, Tamil Nadu, India.
Mallikarjun GundappaDepartment of Biotechnology, School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India.
Shanmugam VelayuthaprabhuDepartment of Biotechnology, School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India. velayuthaprabhu@buc.edu.in.
Kamal ShahInstitute of Pharmaceutical Research, GLA University, Mathura, 281406, UP, India.
Ponmurugan PonnuchamyDepartment of Botany, Sri Kaliswari College, Sivakasi, Virudhunagar, Dist-626130, Tamil Nadu, India.
Suresh Kumar MendemBengaluru Science and Technology Cluster (BeST), IISc Campus, Maleeshwaram, Bengaluru, Karnataka, 560012, India.
P Shivakumar SinghDepartment of Botany, Palamuru University, Mahabubnagar, 509002, TS, India.
Nagendra Singh ChauhanDrugs Testing Laboratory Avam Anusandhan Kendra, Raipur, 492010, Chhattisgarh, India. chauhan.nagendra@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lichen has widespread uses in indigenous medicinal traditions, and it has been used to treat various conditions. Among the various active compounds in the lichen, Usnic acid has unique biological activities. However, the toxicology and the mechanism of action of Usnic acid need to be examined in detail to the extent of clinical trials. Hence, the present research is aimed to isolate usnic acid from the mycobiont culture of Usnea baileyi lichen and explore its toxicological properties and those of pharmacological importance. The methanolic extract of these mycobiont cultures has shown the presence of Usnic acid via column chromatography. The Usnic acid was computationally evaluated using molecular docking studies (GLIDE docking) and MMGBSA energy calculations. The results obtained from TLC, LC-MS, UV-VIS spectrophotometer, NMR spectroscopy

Indexed as

Antineoplastic AgentsBenzofuransLichensUsneaAnimalsAntioxidantsCell Line, TumorHumansMolecular Docking SimulationZebrafishAntineoplastic AgentsAntioxidantsBenzofuransusnic acidAcute toxicityAntimicrobialAntioxidantsApoptosisMelanoma cancerUsnic acid

Identifiers

PMID39520556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.