Evidence map›Paper›PMID 39520365›Full record

ArticleEuropean journal of immunology2025

B Cells With Complementary B Cell Receptors Can Kill Each Other.

Ramakrishna Prabhu Gopalakrishnan, Marius Sigurdsson Østrøm, Frode Miltzow Skjeldal, Oddmund Bakke, Bjarne Bogen, Peter Csaba Huszthy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ramakrishna Prabhu GopalakrishnanDepartment of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Marius Sigurdsson ØstrømDepartment of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Frode Miltzow SkjeldalDepartment of Biosciences, University of Oslo, Oslo, Norway.
Oddmund BakkeDepartment of Biosciences, University of Oslo, Oslo, Norway.
Bjarne BogenDepartment of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Peter Csaba HuszthyDepartment of Immunology, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0003-0184-8989

Funding

Norwegian Research Council 221709South-East Health Authority 2017082
6 · The paper itself

Abstract

B cells differentiate from hematopoietic stem cells in the bone marrow (BM) and migrate as transitional cells to the spleen where final maturation takes place. Due to the enormous diversity in variable (V) regions of B cell receptors for antigen (BCR), B cells with complementary BCRs are likely to be generated. These could encounter each other in the BM or in secondary lymphoid organs. The outcome of such an event is unknown. To study this issue, we used two strains of gene-modified mice whose B cells display complementary BCRs. B cells of one strain express an idiotype

Indexed as

B-LymphocytesReceptors, Antigen, B-CellAnimalsCell DifferentiationMiceMice, Inbred C57BLMice, TransgenicSpleenReceptors, Antigen, B-Cellapoptosisautoimmunityfollicular B cellsidiotopesidiotypic networkmarginal zone B cellstolerance developmenttransitional B cells

Identifiers

PMID39520365
PMCPMC11739674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.