Evidence map›Paper›PMID 39520323›Full record

ArticleACS applied materials & interfaces2024

Wnt 3a-Modified Scaffolds Improve Nerve Regeneration by Boosting Schwann Cell Function.

Ruichao He, Yu Wei, Shi Yan, Jiajie Chen, Yanjun Guan, Xing Xiong, Lijing Liang, Congcong Guan, Haolin Liu, Yiben Ouyang and 8 more

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ruichao HeSchool of Medicine, Nankai University, Tianjin 300071, P. R. China.ORCID 0009-0006-9819-7340
Yu WeiDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.
Shi YanSchool of Medicine, Nankai University, Tianjin 300071, P. R. China.
Jiajie ChenSchool of Medicine, Nankai University, Tianjin 300071, P. R. China.
Yanjun GuanDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.
Xing XiongDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.
Lijing LiangDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.
Congcong GuanSchool of Medicine, Nankai University, Tianjin 300071, P. R. China.
Haolin LiuDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.
Yiben OuyangSchool of Medicine, Nankai University, Tianjin 300071, P. R. China.
Junli WangDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.
Xiwei PengDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.
Jianting YeDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.
Jinjuan ZhaoDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.
Biqin LaiKey Laboratory for Stem Cells and Tissue Engineering, Sun Yat-sen University, Ministry of Education, Guangzhou 510080, P. R. China.
Yu WangSchool of Medicine, Nankai University, Tianjin 300071, P. R. China.
Jiang PengSchool of Medicine, Nankai University, Tianjin 300071, P. R. China.ORCID 0000-0003-4662-9288
Qi QuanDepartment of Orthopedic Surgery, Institute of Orthopedics, The Fourth Medical Center of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing,100048, P. R. China.ORCID 0000-0003-1493-4042

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pivotal approach in engineering artificial peripheral nerve sheaths encompasses the augmentation of the regenerative microenvironment via the manipulation of Schwann cells (SCs). Our investigation employed single-cell sequencing analysis to elucidate the potential functions of Schwann cells and the Wnt pathway in facilitating peripheral nerve regeneration.

Indexed as

Nerve RegenerationRats, Sprague-DawleySchwann CellsSciatic NerveTissue ScaffoldsWnt3A ProteinAnimalsMalePolyestersRatspolycaprolactonePolyestersWnt3A Proteinnerve regenerationNGCperipheral nerve injuryWnt3aWnt signal

Identifiers

PMID39520323
PMCPMC11583969

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.