Evidence map›Paper›PMID 39520259›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Analysis of the Abasic Sites in Breast Cancer Patients With 5 Year Postoperative Treatment Without Recurrence in Taiwan.

Che Lin, Chi-Yen Feng, Gilang P Bahari, Sheng-Min Huang, Cheng-Hao Wei, Qi Xu, Dat Thanh Dinh, Dar-Ren Chen, Po-Hsiung Lin

Abstract read
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In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Alleviating the Global Burden of Cancer Through Prevention and Early Detection.Cancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Che LinComprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua, Taiwan.ORCID 0000-0001-8080-409X
Chi-Yen FengDepartment of Surgery, Da-Chien Health Medical System, Taiwan.
Gilang P BahariDepartment of Environmental Engineering, National Chung Hsing University, Taichung, Taiwan.
Sheng-Min HuangDepartment of Environmental Engineering, National Chung Hsing University, Taichung, Taiwan.
Cheng-Hao WeiDepartment of Environmental Engineering, National Chung Hsing University, Taichung, Taiwan.
Qi XuDepartment of Environmental Engineering, National Chung Hsing University, Taichung, Taiwan.
Dat Thanh DinhGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan.ORCID 0009-0007-3157-4153
Dar-Ren ChenComprehensive Breast Cancer Center, Changhua Christian Hospital, Changhua, Taiwan.ORCID 0000-0002-0897-4374
Po-Hsiung LinDepartment of Environmental Engineering, National Chung Hsing University, Taichung, Taiwan.ORCID 0000-0003-1905-2778

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis prospective study aimed to investigate estrogen-induced carcinogenesis by assessing the background levels of abasic sites (apurinic/apyrimidinic sites, AP sites) in Taiwanese breast cancer patients following 5 years of postoperative treatment without recurrence (5-year survivors) (n = 70). The study also sought to compare the extent of these DNA lesions with those found in healthy controls and in breast cancer patients prior to treatment.

methodsAbasic sites were measured using an aldehyde reactive probe and quantified as the total number of abasic sites per total nucleotides. Characterization of the abasic sites in subjects recruited for this study was conducted using the abasic site cleavage assay using putrescine or T7 exonuclease (T7 Exo) and/or exonuclease III (Exo III).

resultsThe number of abasic sites detected in 5 year survivors (26.7 ± 10.2 per 10

conclusionOverall, these findings suggest clear evidence of treatment-related effects on the reduction of levels of abasic sites as well as on the profile of abasic sites in 5 year survivors.

Indexed as

Breast NeoplasmsAdultAgedDNA DamageFemaleHumansMiddle AgedNeoplasm Recurrence, LocalProspective StudiesTaiwanabasic sitesbiomarkerDNA damageDNA repairoxidative stress

Identifiers

PMID39520259
PMCPMC11550507

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.