Evidence map›Paper›PMID 39520246›Full record

ArticleThe clinical respiratory journal2024

Prognostic Nomogram for Predicting Survival in Asian Patients With Small-Cell Lung Cancer: A Comprehensive Population-Based Study and External Verification.

Yuanli Xia, Jingjing Qu, Yufang Wang, Yanping Zhu, Jianying Zhou, Jianya Zhou

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Article in The clinical respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Yuanli XiaThe Clinical Research Center for Respiratory Diseases of Zhejiang Province, Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0009-0006-5638-2708
Jingjing QuThe Clinical Research Center for Respiratory Diseases of Zhejiang Province, Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yufang WangThe Clinical Research Center for Respiratory Diseases of Zhejiang Province, Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yanping ZhuThe Clinical Research Center for Respiratory Diseases of Zhejiang Province, Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jianying ZhouThe Clinical Research Center for Respiratory Diseases of Zhejiang Province, Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Jianya ZhouThe Clinical Research Center for Respiratory Diseases of Zhejiang Province, Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Funding

General Project of Education Department of Zhejiang Province Y202043420Medicine Health Technology Plan of Zhejiang Province, China 2022KY150Natural Science Foundation of Zhejiang Province LY23H160020Zhejiang Provincial Clinical Research Center for Respiratory Disease 2022E50005
6 · The paper itself

Abstract

backgroundThe incidence of small cell lung cancer (SCLC) among Asian patients is on the rise. Nevertheless, there remains a deficiency in precise prognostic models tailored to the specific needs of this patient population. It is imperative to develop a novel nomogram aimed at forecasting the prognosis of Asian SCLC patients.

methodsThe SEER database supplied data on 661 Asian SCLC patients, who were then divided into training and internal validation sets through a random selection process. In addition, we identified 212 patients from a Chinese medical institution for the purpose of creating an external validation cohort. To forecast survival, we employed both univariate and multivariate analyses. The performance of our nomogram was assessed through calibration plots, the concordance index (C-index), and decision curve analysis (DCA).

resultsFive independent prognostic factors were determined and integrated into the nomogram. C-index values for the training and internal validation cohorts were 0.774 (95% confidence interval [CI] = 0.751-0.797) and 0.731 (95%CI = 0.690-0.772), respectively. In the external validation cohort, the C-index is 0.712 (95% CI = 0.655-0.7692). Calibration curves demonstrated highly accurate predictions. When compared to the AJCC staging system, our model exhibited improved net benefits in DCA. Furthermore, the risk stratification system effectively differentiated patients with varying survival risks.

conclusionWe have created a novel nomogram for predicting the survival of Asian patients with SCLC. This nomogram has been subjected to external validation and has shown its superiority over the conventional TNM staging system. It offers a more precise and reliable means of forecasting the prognosis of Asian SCLC patients.

Indexed as

Lung NeoplasmsNomogramsSEER ProgramSmall Cell Lung CarcinomaAgedAsian PeopleChinaFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisSurvival RateAsian patientsnomogramsmall cell lung cancersurvival prediction

Identifiers

PMID39520246
PMCPMC11549649

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