ArticleTechnology and health care : official journal of the European Society for Engineering and Medicine2024
Study on the correlation between the level of insulin resistance and changes in the degree of cerebral atherosclerosis in non-diabetic patients.
Article in Technology and health care : official journal of the European Society for Engineering and Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCerebral infarction is a health problem of global concern and brings a particular burden to medical treatment.
objectiveTo analyze the correlation between insulin resistance (IR) levels and changes in cerebral atherosclerosis (AS) degree in non-diabetic patients with cerebral infarction.
methodsA total of 134 non-diabetic patients with cerebral infarction who visited the Department of Neurology of our hospital from May 2019 to October 2020 were selected and underwent MRA/CTA (Magnetic resonance angiography/Computed tomography angiography) of cerebral arteries to refine the cerebrovascular imaging data, and according to the results of cerebral AS load, the patients were divided into mild AS group and severe AS group, and the insulin resistance index was calculated with HOMA-IR (homeostasis model assessment of insulin resistance) to evaluate the IR level and HOMA-IR was compared between the two groups. Spearman correlation was used to analyze the correlation between the levels of IR in patients and the changes in cerebral AS load.
results54 individuals had severe AS and 80 patients had mild AS, according to an MRA/CTA of the cerebral arteries. There was a significant difference (P< 0.05) in HOMA-IR between the difficult and gentle AS groups. A significant link between HOMA-IR and the severity of cerebral AS in patients was found using Spearman correlation analysis (r= 0.850, P< 0.05).
conclusionThe IR phenomenon was prevalent in non-diabetic patients with cerebral infarction, and the level of IR was closely related to the severity of cerebral AS.
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