ArticleBiophysical journal2024
Integration of kinetic data into affinity-based models for improved T cell specificity prediction.
Article in Biophysical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Biophysical modeling for accurate T cell specificity prediction of viral and tumor antigens.Nature communications · 2026Article
- More protein-ligand data are needed for AlphaFold-like models to enable drug discovery.Current opinion in structural biology · 2026Review
- A biophysical framework for accurately identifying antigen single-amino acid escape variants and corresponding variant-specific compensatory TCR sequences.bioRxiv : the preprint server for biology · 2026Article
- Feature Selection Enhances Peptide Binding Predictions for TCR-Specific Interactions.bioRxiv : the preprint server for biology · 2024Article
- Feature selection enhances peptide binding predictions for TCR-specific interactions.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) interactions that result in T cell activation are complex and have been distinguished by their equilibrium affinity and kinetic profiles. While prior affinity-based models can successfully predict meaningful TCR-pMHC interactions in many cases, they occasionally fail at identifying TCR-pMHC interactions with low binding affinity. This study analyzes TCR-pMHC systems for which empirical kinetic and affinity data exist and prior affinity-based predictions have failed. We identify criteria for TCR-pMHC systems with available kinetic information where the introduction of a correction factor improves energy-based model predictions. This kinetic correction factor offers a means to refine existing models with additional data and offers molecular insights to help reconcile previously conflicting reports concerning the influence of TCR-pMHC binding kinetics and affinity on T cell activation.
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Registered trials
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