Evidence map›Paper›PMID 39519796›Full record

ArticleMolecules (Basel, Switzerland)2024

Design, Synthesis and Biological Activity Evaluation of β-Carboline Derivatives Containing Nitrogen Heterocycles.

Guiyun Wu, Wenhang Wang, Fulian Li, Chenlu Xu, Yue Zhou, Zhurui Li, Bingqian Liu, Lihui Shao, Danping Chen, Song Bai and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Molecules (Basel, Switzerland) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guiyun WuGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang 550025, China.
Wenhang WangGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang 550025, China.
Fulian LiGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang 550025, China.ORCID 0009-0006-2763-8014
Chenlu XuGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang 550025, China.ORCID 0009-0009-7499-796X
Yue ZhouGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang 550025, China.
Zhurui LiGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang 550025, China.
Bingqian LiuGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang 550025, China.ORCID 0000-0001-5710-7210
Lihui ShaoState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, Guizhou University, Guiyang 550025, China.
Danping ChenGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang 550025, China.
Song BaiResearch Center for Green Chemistry and Ecological Environment Technology, Guizhou Industry Polytechnic College, Guiyang 550008, China.
Zhenchao WangGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang 550025, China.ORCID 0000-0002-9560-7627

Funding

Guizhou Provincial Foundation for Excellent Scholars Program GCC[2023]072National Natural Science Foundation of China 32360689, 22364008, 32260694the National Key R&D Program of China 2023YFD1400400Top Science and Technology Talent Program of Guizhou Education Department 2022075
6 · The paper itself

Abstract

A series of β-carboline derivatives containing nitrogen heterocycles were designed and synthesized. All compounds were screened for their antitumor activity against four human tumor cell lines (A549, K562, PC-3, T47D). Notably, compound

Indexed as

Antineoplastic AgentsApoptosisCarbolinesCell ProliferationDrug DesignHeterocyclic CompoundsCell Line, TumorCell MovementDrug Screening Assays, AntitumorHumansMolecular StructureNitrogenPC-3 CellsReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsCarbolinesHeterocyclic CompoundsNitrogenReactive Oxygen Speciesantitumorapoptosiscell cycleROSβ-carboline derivatives

Identifiers

PMID39519796
PMCPMC11547513

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.