Evidence map›Paper›PMID 39519736›Full record

ArticleMolecules (Basel, Switzerland)2024

Tripodal Quinone-Cyanine G-Quadruplex Ligands as Novel Photosensitizers on Photoinduced Cancer Cell Death.

Junya Muramoto, Takashi Sakamoto

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Junya MuramotoGraduate School of Systems Engineering, Wakayama University, 930 Sakaedani, Wakayama 640-8510, Japan.
Takashi SakamotoGraduate School of Systems Engineering, Wakayama University, 930 Sakaedani, Wakayama 640-8510, Japan.ORCID 0000-0001-5272-7517

Funding

Japan Society for the Promotion of Science 21K05309
6 · The paper itself

Abstract

Guanine-quadruplex (G4) selective photosensitizers have huge potential for photodynamic therapy against various diseases correlated with G4 DNA and G4 RNAs; however, the types of photosensitizer skeletons available are limited. Herein, we investigated the ability of our original G4 ligands, tripodal quinone-cyanine dyes (tpQCy(s)), which were developed as fluorescent probes for G4, to act as photosensitizers for cancer-selective apoptosis inducers. The results indicated that the tpQCy skeleton has great potential for developing G4-targeted cancer-selective photosensitizers for photodynamic therapy. Among the two tpQCys, only QCy(BnBT)

Indexed as

ApoptosisG-QuadruplexesPhotochemotherapyPhotosensitizing AgentsBenzoquinonesCarbocyaninesHeLa CellsHumansLigandsNeoplasmsQuinonesBenzoquinonesCarbocyaninesLigandsPhotosensitizing AgentsquinoneQuinonesapoptosisG4 ligandguanine-quadruplexphotosensitizersreactive oxygen species

Identifiers

PMID39519736
PMCPMC11547667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.