Evidence map›Paper›PMID 39519726›Full record

ArticleMolecules (Basel, Switzerland)2024

20 (S)-Protopanaxadiol Alleviates DRP1-Mediated Mitochondrial Dysfunction in a Depressive Model In Vitro and In Vivo via the SIRT1/PGC-1α Signaling Pathway.

Pengli Guo, Zixian Wang, Li Sun, Zhongmei He, Jianming Li, Jianan Geng, Ying Zong, Weijia Chen, Rui Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pengli GuoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Zixian WangCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Li SunCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Zhongmei HeCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.ORCID 0000-0002-2694-6510
Jianming LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Jianan GengCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Ying ZongCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Weijia ChenCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Rui DuCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.

Funding

Demonstration and Promotion of Sika Deer Breeding and Reproduction, Disease Prevention and Control, Product Processing Industry Technology 202300801-04Modern pharmacological connotation, biological mechanism of action and basic research on the traditional core functions of Sika deer medicinal parts 20220304001YYthe Jilin Province Major Science and Technology Special Project 20220304002YYthe Jilin Province Science and Technology Department Talent Special-deerb sinew chelated calcium preparation key technology and industrialization research 20240601086RCthe study on key technology and industrialization of deer heart peptide product, a special diet that can increase exercise endurance 23JQ08
6 · The paper itself

Abstract

Depression is a complex and common mental illness affecting physical and psychological health.

Indexed as

DepressionDisease Models, AnimalMitochondriaPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSapogeninsSignal TransductionSirtuin 1AnimalsAntidepressive AgentsCell LineCell SurvivalDynaminsMaleMiceAntidepressive AgentsDynaminsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseprotopanaxadiolSapogeninsSirt1 protein, mouseSirtuin 120 (S)-Protopanaxadioldepressiondynamics-related protein 1mitochondrial dysfunctionsirtuin1

Identifiers

PMID39519726
PMCPMC11547436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.