A Simple HPLC-DAD Method for the Therapeutic Monitoring of Clozapine and Related Metabolites in Human Plasma and Urine Samples.

Mircea-Alexandru Comănescu, Dana-Maria Preda, Dalia-Simona Miron, Flavian-Ștefan Rădulescu, Victor Voicu, Andrei-Valentin Medvedovici

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Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Mircea-Alexandru ComănescuDepartment of Analytical & Physical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Ave. # 90-92, 050663 Bucharest, Romania.ORCID 0000-0002-3075-436X

Dana-Maria PredaDepartment of Analytical & Physical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Ave. # 90-92, 050663 Bucharest, Romania.

Dalia-Simona MironCenter for Drug Sciences, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila Bucharest, #6 Traian Vuia Street, 025956 Bucharest, Romania.

Flavian-Ștefan RădulescuCenter for Drug Sciences, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila Bucharest, #6 Traian Vuia Street, 025956 Bucharest, Romania.

Victor VoicuSection of Medical Science, Romanian Academy, Calea Victoriei # 125, 010071 Bucharest, Romania.

Andrei-Valentin MedvedoviciDepartment of Analytical & Physical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Ave. # 90-92, 050663 Bucharest, Romania.ORCID 0000-0003-2647-2906

Funding

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6 · The paper itself

Abstract

Clozapine and its metabolites require close therapeutic monitoring (TDM) in patients due to poor correlation between the administrated doses and resulting plasma concentrations, the narrow therapeutic interval, high inter-individual variability, and the risk of serious side effects once toxic levels are exceeded. The aim of the study was to develop a simple (relatively cheap) LC-UV method for the quantification of clozapine and its metabolites in plasma and urine samples. For sample preparation, liquid-liquid extraction (LLE) in

Indexed as

ClozapineDrug MonitoringLiquid-Liquid ExtractionAntipsychotic AgentsChromatography, High Pressure LiquidHumansAntipsychotic AgentsClozapineclozapineHPLC-DADLLEmetabolitesn-octanolSUPRAS

Identifiers

PMID39519680

DOI10.3390/molecules29215039

PMCPMC11547683

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