Evidence map›Paper›PMID 39519588›Full record

Trial reportNutrients2024

Improvement in Glycolipid Metabolism Parameters After Supplementing Fish Oil-Derived Omega-3 Fatty Acids Is Associated with Gut Microbiota and Lipid Metabolites in Type 2 Diabetes Mellitus.

Jiayue Xia, Shiyu Yin, Junhui Yu, Jiongnan Wang, Xingyi Jin, Yuanyuan Wang, Hechun Liu, Guiju Sun

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiayue XiaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Shiyu YinKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Junhui YuKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.ORCID 0000-0002-5375-0388
Jiongnan WangKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Xingyi JinKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Yuanyuan WangKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Hechun LiuDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China.
Guiju SunKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.ORCID 0000-0001-5969-2185

Funding

NATURAL SCIENCE FOUNDATION OF JIANGSU PROVINCE BK20220708THE NATIONAL NATURAL SCIENCE FOUNDATION OF CHINA 81872618THE NATIONAL NATURAL SCIENCE FOUNDATION OF CHINA 82173509
6 · The paper itself

Abstract

BACKGROUND/

objectivesThis study aimed to investigate the effects of fish oil-derived omega-3 polyunsaturated fatty acids (omega-3 PUFAs) on gut microbiota and serum lipid metabolites in T2DM.

methodsIn a three-month, randomized, double-blind, placebo-controlled study, 110 T2DM patients received either fish oil (

resultsThis study found that fish oil-derived omega-3 PUFAs intervention did not significantly lower the fasting plasma glucose levels when compared with the baseline level (

conclusionsThis study highlights the impact of fish oil-derived omega-3 PUFAs on intestinal microbiota structure and function in patients with type 2 diabetes. The observed decrease in pathogenic bacterial species and the enhancement of beneficial species may have significant implications for gut health and systemic inflammation, both of which are pivotal in managing diabetes. Further research is warranted to comprehensively elucidate the long-term benefits and underlying mechanisms of these microbiota alterations.

Indexed as

Diabetes Mellitus, Type 2Dietary SupplementsFatty Acids, Omega-3Fish OilsGastrointestinal MicrobiomeGlycolipidsLipid MetabolismAdultAgedBlood GlucoseDouble-Blind MethodFemaleGlycated HemoglobinHumansMaleMiddle AgedBlood GlucoseFatty Acids, Omega-3Fish OilsGlycated HemoglobinGlycolipidsblood glucoseblood lipidsglycerophospholipidgut microbiotaomega-3 fatty acidstype 2 diabetes mellitus

Identifiers

PMID39519588
PMCPMC11547733

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.