Evidence map›Paper›PMID 39519555›Full record

ArticleNutrients2024

DNA Methylation Signatures Characterize Gene Expression Modulation in Lung Cancer Patients Affected by Anorexia.

Alessio Molfino, Francesca Ambrosani, Silvia Udali, Giovanni Imbimbo, Sara Moruzzi, Annalisa Castagna, Patrizia Pattini, Federica Tambaro, Cesarina Ramaccini, Maurizio Muscaritoli and 1 more

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In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alessio MolfinoDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-6432-0236
Francesca AmbrosaniUnit of Internal Medicine B, Department of Medicine, School of Medicine, University of Verona, 37129 Verona, Italy.
Silvia UdaliUnit of Internal Medicine B, Department of Medicine, School of Medicine, University of Verona, 37129 Verona, Italy.
Giovanni ImbimboDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Sara MoruzziUnit of Internal Medicine B, Department of Medicine, School of Medicine, University of Verona, 37129 Verona, Italy.
Annalisa CastagnaUnit of Internal Medicine B, Department of Medicine, School of Medicine, University of Verona, 37129 Verona, Italy.ORCID 0000-0002-4650-0823
Patrizia PattiniUnit of Internal Medicine B, Department of Medicine, School of Medicine, University of Verona, 37129 Verona, Italy.ORCID 0000-0003-3679-4458
Federica TambaroDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-8863-3459
Cesarina RamacciniDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Maurizio MuscaritoliDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Simonetta FrisoUnit of Internal Medicine B, Department of Medicine, School of Medicine, University of Verona, 37129 Verona, Italy.ORCID 0000-0002-9606-6711

Funding

Sapienza University of Rome RM11615500F8855D
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe pathophysiology of cancer anorexia is multifactorial and unclear. Transcriptomic analysis from PBMCs RNA showed diverse patterns of gene expression pathways in anorexic cancer patients. We assessed whether the different transcriptomic signatures are modulated by DNA methylation in lung cancer patients presenting with poor appetite.

methodsLung cancer patients and controls were enrolled, and anorexia was assessed by the FAACT-score questionnaire. Genome-wide DNA methylation was determined by Human Infinium MethylationEPIC BeadChip Kit. Data from genome-wide methylation analysis were merged with those from gene expression analysis, previously obtained by RNA sequencing (NGS). Four groups of genes were identified for each comparison: hypermethylated repressed, hypermethylated induced, hypomethylated repressed, and hypomethylated induced.

resultsCancer patients (

conclusionsOur data support that methylation is implicated in cancer-associated anorexia and nutritional derangements among lung cancer patients.

Indexed as

AnorexiaDNA MethylationLung NeoplasmsAgedCase-Control StudiesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedTranscriptomeanorexiaappetiteDNA methylationinflammationlung cancerNGS

Identifiers

PMID39519555
PMCPMC11547925

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