Evidence map›Paper›PMID 39519521›Full record

Trial reportNutrients2024

The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Suet-Kei Wu, Kai-Jie Yang, Wen-Chun Liu, Ikbal Andrian Malau, Halliru Zailani, Cheng-Ho Chang, Shih-Yi Huang, Jane Pei-Chen Chang, Wei-Che Chiu, Kuan-Pin Su

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Evaluating the causal effects of circulating metabolites on major depression disorder.European archives of psychiatry and clinical neuroscience · 2026
    Article
  3. Article
  4. Nutrients · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Suet-Kei WuMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung 404, Taiwan.ORCID 0009-0007-0772-2742
Kai-Jie YangMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung 404, Taiwan.ORCID 0000-0002-3964-9339
Wen-Chun LiuDepartment of Nursing, National Tainan Junior College of Nursing, Tainan 700, Taiwan.ORCID 0000-0001-9048-6363
Ikbal Andrian MalauMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung 404, Taiwan.ORCID 0000-0002-6716-4830
Halliru ZailaniMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung 404, Taiwan.ORCID 0000-0002-0129-7980
Cheng-Ho ChangDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.
Shih-Yi HuangSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0003-2914-5513
Jane Pei-Chen ChangMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung 404, Taiwan.ORCID 0000-0001-5582-0928
Wei-Che ChiuDepartment of Psychiatry, Cathay General Hospital, Taipei 106, Taiwan.ORCID 0000-0001-8549-1432
Kuan-Pin SuMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung 404, Taiwan.ORCID 0000-0002-4501-2502

Funding

An-Nan Hospital, China Medical University, Tainan, Taiwan ANHRF 110-13, 111-52, 112-24, 112-47, 113-24, 113-38, 113-40China Medical University Hospital, Taichung, Taiwan. DMR-110-124, 111-245, 112-097, 112-086, 112-109, 112-232, DMR-HHC-109-11, HHC-109-12, HHC-110-10, and HHC-111-8China Medical University, Taichung, Taiwan ; CMU 110-AWARD-02, 110-N-17, 111-SR-73Higher Education Sprout Project by the Ministry of Education (MOE), Taiwan CMRC-CMA-2National Science and Technology Council (NSTC) NSTC 109-2320-B-038-057-MY3, 110-2321-B-006-004, 110-2811-B-039-507, 110-2320-B-039-048-MY2, 110-2320-B-039-047-MY3, 110-2813-C-039-327-B, 110-2314-B-039-029-MY3, 111-2321-B-006-008, 111-2314-B-039-041-MY3, and 113-2923-B-039-001-MY3
6 · The paper itself

Abstract

objectiveOmega-3 polyunsaturated fatty acids (

methodsA total of 60 patients with MDD participated in this 12-week double-blind randomized controlled trial. They were randomized to either the

resultsThe

conclusionsThese findings suggested that monotherapy of

Indexed as

Antidepressive AgentsFatty Acids, Omega-3Major Depressive DisorderAdultDietary SupplementsDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidFemaleHumansMaleMiddle AgedPilot ProjectsTreatment OutcomeAntidepressive AgentsDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3depressionmonotherapyn-3 PUFAsRCT

Identifiers

PMID39519521
PMCPMC11547719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.