Evidence map›Paper›PMID 39519487›Full record

ArticleNutrients2024

Cytoprotective Effects of Antioxidant Peptides from Red Californian Worm (

Yhoan S Gaviria, José E Zapata, Diego Miedes, Amparo Alegría, Antonio Cilla

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yhoan S GaviriaNutrition and Food Technology Group, Faculty of Pharmaceutical and Food Sciences, University of Antioquia, Medellin 050010, Colombia.ORCID 0000-0002-6946-3893
José E ZapataNutrition and Food Technology Group, Faculty of Pharmaceutical and Food Sciences, University of Antioquia, Medellin 050010, Colombia.ORCID 0000-0003-2733-1515
Diego MiedesNutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.ORCID 0000-0003-2987-5575
Amparo AlegríaNutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.
Antonio CillaNutrition and Food Science Area, Faculty of Pharmacy and Food Sciences, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.ORCID 0000-0001-6532-9032

Funding

Ministerio de Ciencia, Tecnología e Innovación 82040
6 · The paper itself

Abstract

BACKGROUND/

objectivesWhen prooxidants outweigh antioxidants, oxidative stress can occur, causing an accumulation of reactive oxygen species (ROS). This process can lead to cellular damage and plays a role in the development of numerous health conditions. This study aimed to investigate the cytoprotective effects on differentiated Caco-2 cells of hydrolysates derived from the red Californian worm (WH) and their fractions, identify the peptides responsible for this effect, and elucidate the mechanisms involved.

methodsThe WH was obtained through hydrolysis with Alcalase 2.4 L and subsequently fractionated to two fractions (F > 3 kDa and F < 3 kDa) using a ceramic membrane with a molecular weight cutoff of 3 kDa. The peptides found in the F < 3 kDa fraction, demonstrating the highest cytoprotective activity, were then sequenced via liquid chromatography-mass spectrometry analysis (LC-MS/MS), and molecular docking was conducted to elucidate the underlying antioxidant mechanisms.

resultsThe hydrolysate of

conclusionsThese results highlight the WH as a potential source of bioactive peptides for the management of oxidative stress.

Indexed as

AntioxidantsOxidative StressPeptidesAnimalsApoptosisCaco-2 CellsCell DifferentiationCell SurvivalCytoprotectionHumansHydrogen PeroxideHydrolysisMolecular Docking SimulationPolychaetaProtein HydrolysatesReactive Oxygen SpeciesAntioxidantsHydrogen PeroxidePeptidesProtein HydrolysatesReactive Oxygen Speciesantioxidant peptidecytoprotective effectmolecular dockingoxidative stressred Californian worm (Eisenia foetida)

Identifiers

PMID39519487
PMCPMC11547318

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.