ArticleNutrients2024
The Causal Relationship Between Choline Metabolites and Acute Acalculous Cholecystitis: Identifying
Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Potential of lysine succinylation as a therapeutic target for gallstone formation: An insightful strategy.World journal of gastroenterology · 2026Article
- Integrated Metabolic and Inflammatory Clustering Reveals Distinct Risk Profiles for Digestive Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Acute Cholecystitis: Integrated Traditional Chinese and Western Medicine Approaches to Epidemiology, Diagnosis, and Treatment.International journal of general medicine · 2025Review
- Choline Intake and Pelvic Inflammatory Disease Risk: A Cross-Sectional Study Based on NHANES 2013-2018.International journal of women's health · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
backgroundAcute acalculous cholecystitis (AAC) is a type of cholecystitis with high mortality rate while its pathogenesis remains complex. Choline is one of the essential nutrients and is related to several diseases. This study aimed to explore the causal relationship between choline metabolites and AAC and its potential mechanisms.
methodsThis research utilized the two-sample Mendelian randomization method to investigate the causal relationship between choline metabolites and AAC. Additionally, multivariable Mendelian randomization and mediated Mendelian randomization were used to explore potential confounding effects from low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TGs), and coronary artery disease (CAD). Linkage disequilibrium score regression (LDSC), co-localization analysis, and enrichment analysis were used to investigate relevant molecular mechanisms.
resultsThere is a negative causal relationship between total choline (OR [95%CI] = 0.9982 [0.9974, 0.9990],
conclusionsThere is a causal relationship between choline metabolites and cholecystitis, mediated through the protective action of LDL. Our results suggest that
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