Evidence map›Paper›PMID 39519310›Full record

ArticleInternational journal of molecular sciences2024

T Regulatory Cell Subsets Do Not Restore for One Year After Acute COVID-19.

Arthur Aquino, Ekaterina Zaikova, Olga Kalinina, Tatiana L Karonova, Artem Rubinstein, Arina A Mikhaylova, Igor Kudryavtsev, Alexey S Golovkin

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Regulatory T cells in hypoxic environments.Frontiers in immunology · 2026
    Review
  5. Review
  6. A pain from the nose to the head: neurological commitment during long COVID.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arthur AquinoAlmazov National Medical Research Centre, 197341 St. Petersburg, Russia.ORCID 0000-0001-6516-7184
Ekaterina ZaikovaAlmazov National Medical Research Centre, 197341 St. Petersburg, Russia.ORCID 0000-0003-0584-2330
Olga KalininaAlmazov National Medical Research Centre, 197341 St. Petersburg, Russia.ORCID 0000-0003-1916-5705
Tatiana L KaronovaAlmazov National Medical Research Centre, 197341 St. Petersburg, Russia.
Artem RubinsteinAlmazov National Medical Research Centre, 197341 St. Petersburg, Russia.ORCID 0000-0002-8493-5211
Arina A MikhaylovaAlmazov National Medical Research Centre, 197341 St. Petersburg, Russia.
Igor KudryavtsevAlmazov National Medical Research Centre, 197341 St. Petersburg, Russia.
Alexey S GolovkinAlmazov National Medical Research Centre, 197341 St. Petersburg, Russia.ORCID 0000-0002-7577-628X

Funding

Ministry of Science and Higher Education of the Russian Federation Agreement No. 075-15-2022-301
6 · The paper itself

Abstract

COVID-19, caused by SARS-CoV-2, triggers a complex immune response, with T regulatory cells (Tregs) playing a crucial role in maintaining immune homeostasis and preventing excessive inflammation. The current study investigates the function of T regulatory cells during COVID-19 infection and the subsequent recovery period, emphasizing their impact on immune regulation and inflammation control. We conducted a comprehensive analysis of Treg subpopulations in peripheral blood samples from COVID-19 patients at different stages: acute infection, early convalescence, and long-term recovery. Flow cytometry was employed to quantify Tregs including "naïve", central memory (CM), effector memory (EM), and terminally differentiated CD45RA

Indexed as

5'-NucleotidaseApyraseCOVID-19SARS-CoV-2T-Lymphocytes, RegulatoryAdultAgedAntigens, CDCytokinesFemaleFlow CytometryGPI-Linked ProteinsHumansMaleMiddle AgedT-Lymphocyte Subsets5'-NucleotidaseAntigens, CDApyraseCD39 antigenCytokinesENTPD1 protein, humanGPI-Linked ProteinsNT5E protein, humanconvalescent periodCOVID-19multicolor flow cytometrypurinergic signalingT regulatory cells

Identifiers

PMID39519310
PMCPMC11545974

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.