Evidence map›Paper›PMID 39519294›Full record

ArticleInternational journal of molecular sciences2024

Supraspinatus Muscle Regeneration Following Rotator Cuff Tear: A Study of the Biomarkers Pax7, MyoD, and Myogenin.

Eva Kildall Hejbøl, Stephanie Wej Andkjær, Julie Dybdal, Marie Klindt, Sören Möller, Kate Lykke Lambertsen, Henrik Daa Schrøder, Lars Henrik Frich

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eva Kildall HejbølThe Orthopedic Research Unit, Hospital Sønderjylland, Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0002-3462-321X
Stephanie Wej AndkjærThe Orthopedic Research Unit, Hospital Sønderjylland, Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.
Julie DybdalThe Orthopedic Research Unit, Hospital Sønderjylland, Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.
Marie KlindtThe Orthopedic Research Unit, Hospital Sønderjylland, Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.
Sören MöllerOpen Patient Data Explorative Network, Odense University Hospital, 5000 Odense, Denmark.ORCID 0000-0003-0858-4269
Kate Lykke LambertsenDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0001-9276-4902
Henrik Daa SchrøderDepartment of Pathology, Odense University Hospital, 5000 Odense, Denmark.ORCID 0000-0001-7588-235X
Lars Henrik FrichThe Orthopedic Research Unit, Hospital Sønderjylland, Department of Regional Health Research, University of Southern Denmark, 5230 Odense, Denmark.

Funding

Region of Southern Denmark grant no RSD 18-17929)
6 · The paper itself

Abstract

The success of rotator cuff tendon repair relies on both tendon healing and muscle recovery. The objective of this descriptive study was to investigate the regenerative potential of the supraspinatus muscle in rotator cuff tear conditions by quantifying the expression of Pax7, MyoD, and myogenin, basic factors that regulate myogenesis. Muscle biopsies were collected from thirty-three patients aged 34 to 73 years who underwent surgery for a rotator cuff tear affecting the supraspinatus muscle. Among these patients, twenty-seven percent were women, and the age of the lesions ranged from 2 to 72 months post-initial trauma. Biopsies were harvested from the supraspinatus muscle at the end closest to the tendon, and control biopsies were harvested from the ipsilateral deltoid muscle. The densities of immunohistochemically stained Pax7

Indexed as

BiomarkersMyoD ProteinMyogeninPAX7 Transcription FactorRegenerationRotator Cuff InjuriesAdultAgedFemaleHumansMaleMiddle AgedMuscle DevelopmentMuscle, SkeletalRotator CuffBiomarkersMyoD1 myogenic differentiation proteinMyoD ProteinMyogeninPAX7 protein, humanPAX7 Transcription Factormuscle regenerationMyoDmyogenic factorsmyogeninPax7rotator cuff tearsupraspinatus

Identifiers

PMID39519294
PMCPMC11546449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.