Evidence map›Paper›PMID 39519269›Full record

ArticleInternational journal of molecular sciences2024

Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes.

Francisco Díaz-Sáez, Cristina Balcells, Laura Rosselló, Iliana López-Soldado, Montserrat Romero, David Sebastián, Francisco Javier López-Soriano, Sílvia Busquets, Marta Cascante, Wifredo Ricart and 7 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Expression and significance of ependymin-related protein 1 and neuregulin 4 in the serum of patients with polycystic ovary syndrome.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  3. Neuregulin 4 in Insulin Resistance: Mechanisms, Controversies, and Therapeutic Perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Francisco Díaz-SáezDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.ORCID 0000-0002-5881-1928
Cristina BalcellsDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.ORCID 0000-0002-7927-5538
Laura RossellóDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.ORCID 0009-0002-4163-9305
Iliana López-SoldadoDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.
Montserrat RomeroDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.
David SebastiánCIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Francisco Javier López-SorianoDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.
Sílvia BusquetsDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.ORCID 0000-0002-9319-3555
Marta CascanteDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.ORCID 0000-0002-2062-4633
Wifredo RicartDepartment of Medical Sciences, University of Girona, Carrer Emili Grahit, 77, 17003 Girona, Spain.
José Manuel Fernández-RealDepartment of Medical Sciences, University of Girona, Carrer Emili Grahit, 77, 17003 Girona, Spain.ORCID 0000-0002-7442-9323
José María Moreno-NavarreteDepartment of Medical Sciences, University of Girona, Carrer Emili Grahit, 77, 17003 Girona, Spain.ORCID 0000-0002-2883-511X
Julián AragonésResearch Unit, Hospital of Santa Cristina, Research Institute Princesa, University Hospital of la Princesa, Autonomous University of Madrid, c/Maestro Vives, 2, 28009 Madrid, Spain.
Xavier TestarDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.
Marta CampsDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.
Antonio ZorzanoDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.
Anna GumàDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona (UB), Av. Diagonal 643, 08028 Barcelona, Spain.ORCID 0000-0001-9390-5252

Funding

CIBERDEM Instituto de Salud Carlos III XXFundació La Marató de TV3 201626-30Fundació La Marató de TV3 534/C/2016Fundación Ramón Areces CIVP18A3942Generalitat de Catalunya XXMICINN PID2019-106209RB-100MICINN PID2022-137576OB-100
6 · The paper itself

Abstract

Neuregulin 4 (Nrg4) is an adipokine that belongs to the epidermal growth factor family and binds to ErbB4 tyrosine kinase receptors. In 3T3-L1 adipocytes, the downregulation of

Indexed as

3T3-L1 CellsAdipocytesDown-RegulationInsulin ResistanceMitochondriaNeuregulinsOxidative StressAnimalsGTP PhosphohydrolasesHydrogen PeroxideLipogenesisLipolysisMiceTumor Necrosis Factor-alphaGTP PhosphohydrolasesHydrogen PeroxideMfn2 protein, mouseneuregulin-4NeuregulinsTumor Necrosis Factor-alpha3T3-L1 adipocytesErbB4inflammationinsulin resistancemitochondriaNeuregulin 4oxidative stress

Identifiers

PMID39519269
PMCPMC11546241

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.