Evidence map›Paper›PMID 39519241›Full record

ArticleInternational journal of molecular sciences2024

How Do Gepotidacin and Zoliflodacin Stabilize DNA Cleavage Complexes with Bacterial Type IIA Topoisomerases? 1. Experimental Definition of Metal Binding Sites.

Harry Morgan, Robert A Nicholls, Anna J Warren, Simon E Ward, Gwyndaf Evans, Fei Long, Garib N Murshudov, Ramona Duman, Benjamin D Bax

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Harry MorganMedicines Discovery Institute, Cardiff University, Cardiff CF10 3AT, UK.ORCID 0000-0001-7349-1486
Robert A NichollsScientific Computing Department, UKRI Science and Technology Facilities Council, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK.ORCID 0000-0002-8577-8617
Anna J WarrenDiamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK.
Simon E WardMedicines Discovery Institute, Cardiff University, Cardiff CF10 3AT, UK.ORCID 0000-0002-8745-8377
Gwyndaf EvansDiamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK.
Fei LongMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
Garib N MurshudovMRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.ORCID 0000-0001-6483-3587
Ramona DumanDiamond Light Source, Harwell Campus, Didcot, Oxfordshire OX11 0DE, UK.
Benjamin D BaxMedicines Discovery Institute, Cardiff University, Cardiff CF10 3AT, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the challenges for experimental structural biology in the 21st century is to see chemical reactions happen.

Indexed as

DNA CleavageDNA Topoisomerases, Type IIAcenaphthenesBinding SitesCrystallography, X-RayHeterocyclic Compounds, 3-RingManganeseModels, MolecularOxazolidinonesStaphylococcus aureusTopoisomerase II InhibitorsAcenaphthenesDNA Topoisomerases, Type IIgepotidacinHeterocyclic Compounds, 3-RingManganeseOxazolidinonesTopoisomerase II InhibitorsDNA cleavagegepotidacimnovel bacterial topoisomerase inhibitor (NBTI)spirocyclic pyrimidinetrione (SPT)type IIA topoisomerasezoliflodacin

Identifiers

PMID39519241
PMCPMC11546367

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.