Evidence map›Paper›PMID 39519239›Full record

ArticleInternational journal of molecular sciences2024

Amino Acid Compound 2 (AAC2) Treatment Counteracts Insulin-Induced Synaptic Gene Expression and Seizure-Related Mortality in a Mouse Model of Alzheimer's Disease.

Zhijie Deng, Aejin Lee, Tao Lin, Sagarika Taneja, Devan Kowdley, Jacob H Leung, Marykate Hill, Tianyi Tao, Julie Fitzgerald, Lianbo Yu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhijie DengDepartment of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Aejin LeeDepartment of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-7780-4961
Tao LinDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Sagarika TanejaDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Devan KowdleyDepartment of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Jacob H LeungDepartment of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Marykate HillDepartment of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.
Tianyi TaoDepartment of Neurological Surgery, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Julie FitzgeraldDepartment of Neuroscience, The Ohio State University, Columbus, OH 43210, USA.
Lianbo YuDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, USA.
Joshua J BlakesleeDepartment of Horticulture and Crop Science, Ohio Agricultural Research and Development Center (OARDC), The Ohio State University, Columbus, OH 43210, USA.
Kristy TownsendDepartment of Neurological Surgery, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Zachary M WeilDepartment of Neuroscience, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-3758-1809
Jon R ParquetteDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-4803-028X
Ouliana ZiouzenkovaDepartment of Human Sciences, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-2449-2591

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Diabetes is a major risk factor for Alzheimer's disease (AD). Amino acid compound 2 (AAC2) improves glycemic and cognitive functions in diabetic mouse models through mechanisms distinct from insulin. Our goal was to compare the effects of AAC2, insulin, and their nanofiber-forming combination on early asymptomatic AD pathogenesis in APP/PS1 mice. Insulin, but not AAC2 or the combination treatment (administered intraperitoneally every 48 h for 120 days), increased seizure-related mortality, altered the brain fat-to-lean mass ratio, and improved specific cognitive functions in APP/PS1 mice. NanoString and pathway analysis of cerebral gene expression revealed dysregulated synaptic mechanisms, with upregulation of

Indexed as

Alzheimer DiseaseDisease Models, AnimalInsulinSeizuresAnimalsBrainGene Expression RegulationMaleMiceMice, TransgenicSynapsesInsulinAlzheimer’s diseasecognitivedementiadiabetesdipeptidesepilepsyinsulinnanofibersnanomaterialsseizuressynapses

Identifiers

PMID39519239
PMCPMC11546384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.