Evidence map›Paper›PMID 39519177›Full record

ArticleInternational journal of molecular sciences2024

Noggin-Loaded PLA/PCL Patch Inhibits BMP-Initiated Reactive Astrogliosis.

James Hawes, Ana Gonzalez-Manteiga, Kendall P Murphy, Marina Sanchez-Petidier, Victoria Moreno-Manzano, Bedika Pathak, Kristin Lampe, Chia-Ying Lin, Jose L Peiro, Marc Oria

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

James HawesCenter for Fetal and Placental Research, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Ana Gonzalez-ManteigaDepartment of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.ORCID 0000-0001-8309-971X
Kendall P MurphyCenter for Fetal and Placental Research, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Marina Sanchez-PetidierNeuronal and Tissue Regeneration Laboratory, Prince Felipe Research Institute, 46512 Valencia, Spain.
Victoria Moreno-ManzanoNeuronal and Tissue Regeneration Laboratory, Prince Felipe Research Institute, 46512 Valencia, Spain.ORCID 0000-0002-6035-9491
Bedika PathakCenter for Fetal and Placental Research, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Kristin LampeCenter for Fetal and Placental Research, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.ORCID 0000-0002-7570-2096
Chia-Ying LinConvergent Bioscience and Technology Institute, Department of Biomedical Engineering and Informatics, Indiana University, Indianapolis, IN 46202, USA.
Jose L PeiroCenter for Fetal and Placental Research, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Marc OriaCenter for Fetal and Placental Research, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.ORCID 0000-0001-9132-9271

Funding

A Novel Smart Patch for the Fetoscopic Procedure to Repair Spina BifidaR01NS103992 · NINDS · UNIVERSITY OF CINCINNATI · PI LIN, CHIA-YING JAMES, PEIRO IBANEZ, JOSE LUIS · 2019 to 2023
$2.4M
NIH/NINDS 1R01NS103992
6 · The paper itself

Abstract

Myelomeningocele (MMC) is a congenital birth defect of the spine and spinal cord, commonly treated clinically through prenatal or postnatal surgery by repairing the unclosed spinal canal. Having previously developed a PLA/PCL polymer smart patch for this condition, we aim to further expand the potential therapeutic options by providing additional cellular and biochemical support in addition to its mechanical properties. Bone morphogenetic proteins (BMPs) are a large class of secreted factors that serve as modulators of development in multiple organ systems, including the CNS. We hypothesize that our smart patch mitigates the astrogenesis induced, at least partly, by increased BMP activity during MMC. To test this hypothesis, neural stem or precursor cells were isolated from rat fetuses and cultured in the presence of Noggin, an endogenous antagonist of BMP action, with recombinant BMPs. We found that the developed PLA/PCL patch not only serves as a biocompatible material for developing neural stem cells but was also able to act as a carrier for BMP-Notch pathway inhibitor Noggin, effectively minimizing the effect of BMP2 or BMP4 on NPCs cultured with the Noggin-loaded patch.

Indexed as

Bone Morphogenetic Protein 2Bone Morphogenetic Protein 4Carrier ProteinsGliosisPolyestersAnimalsBone Morphogenetic ProteinsCells, CulturedNeural Stem CellsNoggin ProteinRatsRats, Sprague-DawleyBmp2 protein, ratBmp4 protein, ratBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Bone Morphogenetic ProteinsCarrier ProteinsNoggin ProteinpolycaprolactonePolyesterspoly(lactide)astrogliosismyelomeningoceleneural precursor cellsnogginPLA/PCL polymer smart patch

Identifiers

PMID39519177
PMCPMC11545872

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.