Evidence map›Paper›PMID 39519147›Full record

ArticleInternational journal of molecular sciences2024

Pathological Alterations in Heart Mitochondria in a Rat Model of Isoprenaline-Induced Myocardial Injury and Their Correction with Water-Soluble Taxifolin.

Natalia V Belosludtseva, Tatyana A Uryupina, Lyubov L Pavlik, Irina B Mikheeva, Eugeny Yu Talanov, Natalya I Venediktova, Dmitriy A Serov, Mikhail R Stepanov, Mikhail A Ananyan, Galina D Mironova

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Natalia V BelosludtsevaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.ORCID 0000-0001-5707-6557
Tatyana A UryupinaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.
Lyubov L PavlikInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.
Irina B MikheevaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.ORCID 0000-0001-8054-0477
Eugeny Yu TalanovInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.ORCID 0000-0001-6227-7409
Natalya I VenediktovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.ORCID 0000-0002-8544-6858
Dmitriy A SerovProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov St. 38, 119991 Moscow, Russia.ORCID 0000-0002-6049-5602
Mikhail R StepanovAdvanced Technologies Ltd., 119333 Moscow, Russia.
Mikhail A AnanyanAdvanced Technologies Ltd., 119333 Moscow, Russia.
Galina D MironovaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.

Funding

Russian Science Foundation 23-25-00441
6 · The paper itself

Abstract

Mitochondrial damage and associated oxidative stress are considered to be major contributory factors in cardiac pathology. One of the most potent naturally occurring antioxidants is taxifolin, especially in its water-soluble form. Herein, the effect of a 14-day course of the peroral application of the water-soluble taxifolin (aqTAX, 15 mg/kg of body weight) on the progression of ultrastructural and functional disorders in mitochondria and the heart's electrical activity in a rat model of myocardial injury induced with isoprenaline (ISO, 150 mg/kg/day for two consecutive days,

Indexed as

AntioxidantsIsoproterenolMitochondria, HeartOxidative StressQuercetinAnimalsDisease Models, AnimalGlutathione PeroxidaseMaleMyocardiumMyocytes, CardiacRatsRats, WistarSuperoxide DismutaseAntioxidantsGlutathione PeroxidaseIsoproterenolQuercetinSuperoxide Dismutasetaxifolinantioxidant enzymesISO-induced myocardial injurylipid peroxidationmitochondriaoxidation phosphorylationoxidative damageultrastructural alterationswater-soluble taxifolin

Identifiers

PMID39519147
PMCPMC11547074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.